TNF-Related Apoptosis Inducing Ligand/Apo2L Protein (Recombinant)

Category

Proteins And Peptides
Clonality

N/A
Raised in

N/A
Target

Related Apoptosis Inducing Ligand/Apo2L Protein
Immunogen

see included datasheet or contact us
Species reactivity

Human, Mouse, Rat (for other species please inquire)
Purification

Affinity purified
Applications

WB (for other applications please contact us)
Stock availability

Shipped within 5-10 working days.
Storage conditions

Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Footnote

This product is for research use only.
Other products
Description

This 1 is suited for programmed cell-death studies. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
Source

Recombinants or rec. proteins
Group

recombinants
Gene

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

Gene target

TNF-Related Ligand/Apo2L Protein
Gene symbol

TNF, TNFRSF1A, TNFRSF1B, LTBR
Short name

TNF- Apoptosis Ligand/Apo2L Protein (Recombinant)
Technique

Recombinant, apoptosis, apoptosis pathway, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Abbexa advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Label

Unconjugated
Alternative name

tumor necrosis factor-Related programmed cellular destruction Inducing Ligand/Apo2L Protein (Rec.)
Alternative technique

rec, celldeath
Alternative to gene target

tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943

Identity

HGNC:11916
Gene

TNFRSF1A
Long gene name

TNF receptor superfamily member 1A
Synonyms gene
- TNFR1
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1A
Synonyms
- TNF-R
- TNFAR
- TNFR60
- TNF-R-I
- CD120a
- TNF-R55
GenBank acession
- M75866
Locus

12p13.31
Discovery year

1991-01-15
Entrez gene record

7132
Pubmed identfication
- 1655358
- 2158863
RefSeq identity
- NM_001065
Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
VEGA ID

OTTHUMG00000168267
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_193

Identity

HGNC:11917
Gene

TNFRSF1B
Long gene name

TNF receptor superfamily member 1B
Synonyms gene
- TNFR2
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1B
Synonyms
- TNFBR
- TNFR80
- TNF-R75
- TNF-R-II
- p75
- CD120b
GenBank acession
- M32315
Locus

1p36.22
Discovery year

1991-01-15
Entrez gene record

7133
Pubmed identfication
- 2158863
- 8702885
RefSeq identity
- NM_001066
Classification
- CD molecules
- MicroRNA protein coding host genes
- Tumor necrosis factor receptor superfamily
VEGA ID

OTTHUMG00000001829

Name

Primary Cell Culture
Concept

Scope note: The initial culturing of cells derived directly from fresh TISSUES.
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data