TNF-R1 Antibody

• Catalog number
  3125-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  TNF-RI
• Target Alternative Name
  TNF-R1, Tumor Necrosis Factor type I, TNFRSF1A, TNFAR, TNF-R55, TNFR60, p55, CD120a
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat, hamster, bovine, rabbit, monkey
• Immunogen Sequence
  Synthetic peptide surrounding amino acid 32 of human TNF-RI
• Accession
  P25118
• Gene Id
  21937
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.2 mg/ml
• Formulation
  100 µg (0.2 mg/ml) affinity purified rabbit anti-TNF-R1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
• Purification
  Affinity purified
• Application
  Western blot, Immunohistochemistry
• Application And Usages
  Western blotting (0.5-4 µg/ml) and in Immunohistochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually. The antibody detects cdc42 of human, mouse, rat, and bovine origins.
• Description
  Tumor necrosis factor receptor 1 and 2 (TNF-R1 and TNF-R2) are 55 and 75 kDa. While TNF-R1 and TNF-R2 share 28% sequence homology in the extracellular domains, their intracellular domains lack sequence homology, sμggesting that they differ in their internal signal transduction pathways. TNF-R1 contains an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal throμgh its interaction with TRADD (TNF-R1 associated death domain protein), and subsequent interactions with FADD. TNF-R1 can also activate the transcription factor NFkB via TRAF2 (TNF receptor associated factor 2). The cytoplasmic domain of TNF-R1 can directly interact with Jak kinase, thereby activating the JAK/STAT signal transduction cascade.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Gene
  Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.
• French translation
  anticorps

• Gene target
  TNF-R1  
• Gene symbol
  TNFRSF1A, TNF, C17orf75, CDCA7L, TNFRSF1B, CNEP1R1, LTBR, CXCL11, PNPLA7, PCAT6
• Short name
  TNF-R1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  tumor necrosis factor-R1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943

Gene info

• Identity
  HGNC:11916
• Gene
  TNFRSF1A
• Long gene name
  TNF receptor superfamily member 1A
• Synonyms gene
  • TNFR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1A
• Synonyms
  • TNF-R
  • TNFAR
  • TNFR60
  • TNF-R-I
  • CD120a
  • TNF-R55
• GenBank acession
  • M75866
• Locus
  12p13.31
• Discovery year
  1991-01-15
• Entrez gene record
  7132
• Pubmed identfication
  • 1655358
  • 2158863
• RefSeq identity
  • NM_001065
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168267
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_193

Gene info

• Identity
  HGNC:11892
• Gene
  TNF
• Long gene name
  tumor necrosis factor
• Synonyms gene
  • TNFA
• Synonyms gene name
  • tumor necrosis factor (TNF superfamily, member 2)
• Synonyms
  • TNFSF2
  • DIF
  • TNF-alpha
• Synonyms name
  • TNF superfamily, member 2
• GenBank acession
  • X02910
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  7124
• Pubmed identfication
  • 2413547
  • 6392892
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000031194

Gene info

• Identity
  HGNC:30173
• Gene
  C17orf75
• Long gene name
  chromosome 17 open reading frame 75
• Synonyms
  • NJMU-R1
  • SRI2
• Synonyms name
  • sensitization to ricin complex subunit 2
• GenBank acession
  • AB062437
• Locus
  17q11.2
• Discovery year
  2006-01-12
• Entrez gene record
  64149
• Pubmed identfication
  • 23394947
  • 29426865
• RefSeq identity
  • NM_022344
• VEGA ID
  OTTHUMG00000179585

Gene info

• Identity
  HGNC:30777
• Gene
  CDCA7L
• Long gene name
  cell division cycle associated 7 like
• Synonyms gene name
  • cell division cycle associated 7-like
• Synonyms
  • RAM2
  • R1
  • JPO2
• Locus
  7p15.3
• Discovery year
  2005-05-13
• Entrez gene record
  55536
• Pubmed identfication
  • 16829576
• RefSeq identity
  • NM_018719
• VEGA ID
  OTTHUMG00000128429

Gene info

• Identity
  HGNC:11917
• Gene
  TNFRSF1B
• Long gene name
  TNF receptor superfamily member 1B
• Synonyms gene
  • TNFR2
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1B
• Synonyms
  • TNFBR
  • TNFR80
  • TNF-R75
  • TNF-R-II
  • p75
  • CD120b
• GenBank acession
  • M32315
• Locus
  1p36.22
• Discovery year
  1991-01-15
• Entrez gene record
  7133
• Pubmed identfication
  • 2158863
  • 8702885
• RefSeq identity
  • NM_001066
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000001829

Gene info

• Identity
  HGNC:26759
• Gene
  CNEP1R1
• Long gene name
  CTD nuclear envelope phosphatase 1 regulatory subunit 1
• Synonyms gene
  • C16orf69
  • TMEM188
• Synonyms gene name
  • chromosome 16 open reading frame 69
  • transmembrane protein 188
• Synonyms
  • FLJ38101
  • NEP1-R1
• Synonyms name
  • nuclear envelope phosphatase 1-regulatory subunit 1
• GenBank acession
  • AK095420
• Locus
  16q12.1
• Discovery year
  2006-04-07
• Entrez gene record
  255919
• Pubmed identfication
  • 22134922
• RefSeq identity
  • NM_153261
• VEGA ID
  OTTHUMG00000173447

Gene info

• Identity
  HGNC:6718
• Gene
  LTBR
• Long gene name
  lymphotoxin beta receptor
• Synonyms gene
  • D12S370
• Synonyms
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNF-R-III
  • TNFRSF3
• Synonyms name
  • TNFR superfamily, member 3
• GenBank acession
  • L04270
• Locus
  12p13.31
• Discovery year
  1996-03-12
• Entrez gene record
  4055
• Pubmed identfication
  • 8171323
  • 8486360
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000168356

Gene info

• Identity
  HGNC:10638
• Gene
  CXCL11
• Long gene name
  C-X-C motif chemokine ligand 11
• Synonyms gene
  • SCYB9B
  • SCYB11
• Synonyms gene name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 11
  • chemokine (C-X-C motif) ligand 11
• Synonyms
  • H174
  • b-R1
  • I-TAC
  • IP-9
• GenBank acession
  • U66096
• Locus
  4q21.1
• Discovery year
  1998-06-23
• Entrez gene record
  6373
• Pubmed identfication
  • 9730616
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000130101

Gene info

• Identity
  HGNC:24768
• Gene
  PNPLA7
• Long gene name
  patatin like phospholipase domain containing 7
• Synonyms gene
  • C9orf111
• Synonyms gene name
  • chromosome 9 open reading frame 111
  • patatin-like phospholipase domain containing 7
• Synonyms
  • FLJ43070
  • FLJ31318
  • FLJ44279
  • RP11-48C7.2
  • NTEL1
  • NTE-R1
• GenBank acession
  • AK126267
• Locus
  9q34.3
• Discovery year
  2004-03-25
• Entrez gene record
  375775
• Pubmed identfication
  • 16799181
  • 12640454
  • 19029121
• RefSeq identity
  • NM_152286
• Classification
  • Patatin like phospholipase domain containing
• VEGA ID
  OTTHUMG00000020990

Gene info

• Identity
  HGNC:43714
• Gene
  PCAT6
• Long gene name
  prostate cancer associated transcript 6
• Synonyms gene
  • KDM5B-AS1
• Synonyms gene name
  • KDM5B antisense RNA 1 (head to head)
  • prostate cancer associated transcript 6 (non-protein coding)
• Synonyms
  • ncRNA-a2
  • PCAN-R1
  • KDM5BAS1
  • onco-lncRNA-96
• Synonyms name
  • prostate cancer-associated noncoding RNA 1
• GenBank acession
  • BI962506
  • AI806248
• Locus
  1q32.1
• Discovery year
  2012-02-02
• Entrez gene record
  100506696
• Pubmed identfication
  • 20887892
  • 23728290
• RefSeq identity
  • NR_046325
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000041399

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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