TMP-153

Alternative_name

N-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N'-(2,4-difluorophenyl)-urea
Description

TMP-153 is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC₅₀ of 5 to 10 nM. It has potency to inhibit cholesterol esterification and reduces its influx into the plasma of rats and hamsters. TMP-153 is shown toxicity to prion infected neuronal (ScGT1) cells. It might have potential to increase caspase-3 activity and prostaglandin E2 production in ScGT1 Cells.
CAS Number

128831-46-9
Structure Available

Yes
Molecular Formula

C₂₄H₁₈ClF₂N₃O
Molecular Weight

437.88
Cell Permeable

Yes
Purity

≥98% by TLC
Solubilities

DMSO (~25 mg/ml)
Handling

Protect from air and light
Tag Line

selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT)
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

125289
PubChem CID Link
SMILES

CC1=C(C=C2C(=C1)C(=C(C=N2)NC(=O)NC3=C(C=C(C=C3)F)F)C4=CC=CC=C4Cl)C
InChi

InChI=1S/C24H18ClF2N3O/c1-13-9-17-21(10-14(13)2)28-12-22(23(17)16-5-3-4-6-18(16)25)30-24(31)29-20-8-7-15(26)11-19(20)27/h3-12H,1-2H3,(H2,29,30,31)
InChi Key

FFKNNBNIAHVVCU-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes