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Long name
TLX2 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
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Also known as
Anti-TLX2 PAb ALEXA FLUOR 647
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 647
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
TLX2
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Specificity
This is a highly specific antibody against TLX2.
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Modification
Unmodified
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Modification Site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TLX2
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
T-cell leukemia homeobox protein 2 (TLX2), also known as homeobox protein Hox-11L1 (HOX11L1), neural crest homeobox protein (NCX) or ENX, is a 284 amino acid member of the TLX homeobox family. The mouse homolog, Tlx2, has been detected in dorsal-root ganglia, cranial and entric-nerve gangla, parasympathetic ganglia and adrenal glands in mouse embryos and in the adrenal glands, intestine and heart of adult mice. The expression pattern of Tlx2, which is restricted to tissues derived from nerual crest cells, suggests that it may play a role in the proliferation or differentiation of the enteric peripheral nervous system. TLX2, which is localized to the nucleus, is highly homologous to mouse Tlx2, and shares several critical domains, including an enhancer element in the promotor that is crucial for tissue-specific expression. Mutations in the gene encoding mouse Tlx2 lead to congenital anomalies closely resembling neuronal intestinal dysplasia in humans. Thus, TLX2 is thought to play a role in this disease, which is a rare condition characterized by hyperplasia of submucosal plexus with giant submucosal ganglia and increased acetylcholinesterase activity in nerve fiber around submucosal blood vessels.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
650nm/665nm
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Synonyms
Enx; homeo box 11 like 1; Homeobox protein Hox 11L1; Homeobox TLX 2; HOX11L1; NCX; Neural crest homeobox protein; PMUR10F; T cell leukemia homeobox protein 2; T cell leukemia, homeobox 2.
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Properties
For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-TLX2 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor, ALEXA FLUOR 647
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French translation
anticorps
