TLR3 Antibody

• Catalog number
  F44372-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS pH 7.4 with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TLR3
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
• Notes
  Titration of the TLR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This TLR3 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O15455
• Purity
  Antigen affinity
• Description
  The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
• Immunogen
  This TLR3 antibody was produced from rabbits immunized with TLR3 recombinant protein.
• Storage
  Aliquot the TLR3 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TLR3  
• Gene symbol
  TLR3
• Short name
  Anti-TLR3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to TLR3
• Alternative technique
  antibodies
• Alternative to gene target
  toll-like receptor 3, CD283 and IIAE2, TLR3 and IDBG-47294 and ENSG00000164342 and 7098, protein binding, Cell surfaces, Tlr3 and IDBG-152685 and ENSMUSG00000031639 and 142980, TLR3 and IDBG-628571 and ENSBTAG00000008682 and 281535

Gene info

• Identity
  HGNC:11849
• Gene
  TLR3
• Long gene name
  toll like receptor 3
• Synonyms gene name
  • toll-like receptor 3
• Synonyms
  • CD283
• GenBank acession
  • U88879
• Locus
  4q35.1
• Discovery year
  1998-06-25
• Entrez gene record
  7098
• Pubmed identfication
  • 9435236
• Classification
  • Toll like receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000160345
• Locus Specific Databases
  • TLR3base: Mutation registry for Influenza-associated encephalopathy
  • LRG_117

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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