TLE4 Antibody, Cy7 Conjugated

TLE4 Antibody, Cy7 Conjugated is available 1 time from Bioss primary conjugated antibodies labs

  • Long name
    TLE4 Polyclonal Antibody, Cy7 Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
  • Specificity
    This is a highly specific antibody against TLE4.
  • Modification
  • Modification site
  • Clonality
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic peptide derived from human TLE4
  • Gene ID number
  • Tested applications
  • Recommended dilutions
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
  • Synonyms
    B lymphocyte gene 1; B lymphocyte gene 1; enhancer of split groucho 4; enhancer of split groucho 4; ESG4; ESG4; KIAA1261; TIM; TIM1; timeless Drosophila homolog; TLE4; transducin-like enhancer of split 4; transducin-like enhancer of split 4; TLE4_HUMAN.
  • Gene target
  • Short name
    TLE4 Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
  • Alternative name
    TLE4 (Antibody to), cyanine 7 coupled
  • Alternative technique

bs-12403R-Cy7 | TLE4 Antibody, Cy7 Conjugatedsize: 0.1ml | 431.06 USD

  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugated
    These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
  • Additional conjugation
  • French translation
1. Gene info
  • Identity
  • Gene
  • Long gene name
    transducin like enhancer of split 4
  • Synonyms gene name
    • transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • WD repeat domain containing
  • Havana BLAST/BLAT
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
Product images
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TLE4 Antibody, Cy7 Conjugated -
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