Tivantinib

• Catalog number
  B1546-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione; ARQ197
• Description
  Tivantinib (ARQ-197) is a potent, cell-permeable inhibitor of c-Met with potential antineoplastic activity. Tivantinib binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.
• CAS Number
  905854-02-6
• Structure Available
  Yes
• Molecular Formula
  C₂₃H₁₉N₃O₂
• Molecular Weight
  369.41
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent, cell-permeable inhibitor of c-Met with potential antineoplastic activity.
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  11494412
• PubChem CID Link
• SMILES
  C1CC2=CC=CC3=C2N(C1)C=C3C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
• InChi
  InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m0/s1
• InChi Key
  UCEQXRCJXIVODC-PMACEKPBSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Tivantinib  
• Short name
  Tivantinib
• Alternative name
  Tivantinib

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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