TIMP-3 (Tissue Inhibitor of MMP's), residue 170-188, Clone: 136-13H4, Mouse Monoclonal antibody-Human, Rabbit; paraffin, IH/WB

• Catalog number
  YMCAF8550
• Price
  Please ask
• Size
  0.5mg

• Alternative name 1
  TIMP-3 (Tissue Inhibitor of MMP's), residue 170-188, Clone: 136-13H4, Mab anti-Human, Rabbit; paraffin, IH/WB
• Alternative name 2
  TIMP-3 (Tissue Inhibitor of MMP's), residue 170-188, Clone: 136-13H4, Mab antibody-Human, Rabbit; paraffin, IH/WB
• Alternative name 3
  TIMP-3 (Tissue Inhibitor of MMP's), residue 170-188, Clone: 136-13H4, Mab antibody-Homo sapiens, Rabbit; paraffin, IH/WB
• Alternative name 4
  anti-TIMP-3 Tissue Inhibitor of MMP's residue 170-188 Clone: 136-13H4
• Alternative name 5
  TIMP-3 Tissue Inhibitor of MMP's residue 170-188 Clone: 136-13H4
• Clonality
  Monoclonal Antibody
• Description
  This is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against. If used correctly and according the protocol, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications. Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches; in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required.
• Storage and handling
  Generally, antibodies that are lyophilized can be transported at ambient temperature and stored for short terms at +4 degrees Celsius, for longer periods - at -20 . Antibodies in a liquid form can be shipped and stored for a short period of time at +4 degrees Celsius, for long term storage (up to one year) 25-50% glycerol or ethylene glycol should be added and then the container has to be stored at -20°C.
• Advisory
  To keep the quality and the affinity of the antibody cycles of freezing and thawing should be avoided. For antibodies in a liquid form or reconstituted lyophilized antibodies small amounts of the soultion could be captured on the cap or the walls of the container. Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom.
• Properties
  If you buy Antibodies supplied by accurate-monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. 6
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes. Rabbits are used for polyclonal antibody production by accurate-monoclonals. Rabbit antibodies are very stable and can be stored for several days at room temperature. accurate-monoclonals adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus, Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  TIMP-3   Tissue   Inhibitor   MMP's   residue   170-188   136-13H4   Monoclonal   paraffin  
• Gene symbol
  TIMP3, MMP14, MMP24, MMP28, TIMP1, MMP17, MIR188, MIR136, MMP15, MMP25
• Short name
  TIMP-3 (Tissue Inhibitor of MMP's), residue 170-188, Clone: 136-13H4, Mouse Monoclonal antibody- , Rabbit; paraffin, IH/
• Technique
  Mouse monoclonal, Antibody, paraffin, Rabbit, tissue, Mouse, WB, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals, tissues, Western Blot on a membrane
• Host
  mouse monoclonal, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG. Rabbits
• Species
  Human, Humans, Mouses
• Alternative name
  TIMP-3 (Tissue suppressor on MMP's), residue 170-188, clonality: 136-13H4, Mouse monoclonal (antibody to-)-H. sapiens, production species: rabbit; paraffin, IH/Western Blot
• Alternative technique
  antibodies, tissues, rabbit-anti, murine
• Tissue
  tissue

Gene info

• Identity
  HGNC:11822
• Gene
  TIMP3
• Long gene name
  TIMP metallopeptidase inhibitor 3
• Synonyms gene
  • SFD
• Synonyms gene name
  • tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
• Locus
  22q12.3
• Discovery year
  1993-04-12
• Entrez gene record
  7078
• Pubmed identfication
  • 8188246
  • 12652295
• RefSeq identity
  • NM_000362
• Classification
  • Tissue inhibitor of metallopeptidases
• VEGA ID
  OTTHUMG00000030784
• Locus Specific Databases
  • Mutations of the Tissue Inhibitor of Metalloproteases 3 Gene

Gene info

• Identity
  HGNC:7160
• Gene
  MMP14
• Long gene name
  matrix metallopeptidase 14
• Synonyms gene name
  • matrix metalloproteinase 14 (membrane-inserted)
  • matrix metallopeptidase 14 (membrane-inserted)
• Synonyms
  • MT1-MMP
• Synonyms name
  • membrane type 1 metalloprotease
  • membrane type 1-matrix metalloproteinase
• Locus
  14q11.2
• Discovery year
  1994-11-20
• Entrez gene record
  4323
• Pubmed identfication
  • 8015608
• RefSeq identity
  • NM_004995
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000028704

Gene info

• Identity
  HGNC:7172
• Gene
  MMP24
• Long gene name
  matrix metallopeptidase 24
• Synonyms gene name
  • matrix metalloproteinase 24 (membrane-inserted)
  • matrix metallopeptidase 24 (membrane-inserted)
• Synonyms
  • MT5-MMP
• Synonyms name
  • membrane-type 5 matrix metalloproteinase
• GenBank acession
  • AF131284
• Locus
  20q11.22
• Discovery year
  1999-08-06
• Entrez gene record
  10893
• Pubmed identfication
  • 10363975
• RefSeq identity
  • NM_006690
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000032330

Gene info

• Identity
  HGNC:14366
• Gene
  MMP28
• Long gene name
  matrix metallopeptidase 28
• Synonyms gene name
  • matrix metalloproteinase 28
• Synonyms
  • MMP-25
  • MM28
  • EPILYSIN
  • MMP-28
• GenBank acession
  • AF315683
• Locus
  17q12
• Discovery year
  2001-01-09
• Entrez gene record
  79148
• Pubmed identfication
  • 11121398
  • 11255011
• RefSeq identity
  • NM_024302
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000188387

Gene info

• Identity
  HGNC:11820
• Gene
  TIMP1
• Long gene name
  TIMP metallopeptidase inhibitor 1
• Synonyms gene
  • TIMP
  • CLGI
• Synonyms gene name
  • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
• Synonyms
  • EPO
• Locus
  Xp11.3
• Discovery year
  1986-01-01
• Entrez gene record
  7076
• RefSeq identity
  • NM_003254
• Classification
  • Tissue inhibitor of metallopeptidases
• VEGA ID
  OTTHUMG00000021447
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:7163
• Gene
  MMP17
• Long gene name
  matrix metallopeptidase 17
• Synonyms gene name
  • matrix metalloproteinase 17 (membrane-inserted)
  • matrix metallopeptidase 17 (membrane-inserted)
• Synonyms
  • MT4-MMP
• GenBank acession
  • X89576
• Locus
  12q24.33
• Discovery year
  1996-11-13
• Entrez gene record
  4326
• Pubmed identfication
  • 9878265
• RefSeq identity
  • NM_016155
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000168050

Gene info

• Identity
  HGNC:31559
• Gene
  MIR188
• Long gene name
  microRNA 188
• Synonyms gene
  • MIRN188
• Synonyms
  • hsa-mir-188
• Locus
  Xp11.23
• Discovery year
  2004-04-23
• Entrez gene record
  406964
• RefSeq identity
  • NR_029708
• Classification
  • MicroRNA MIR188/532 family

Gene info

• Identity
  HGNC:31522
• Gene
  MIR136
• Long gene name
  microRNA 136
• Synonyms gene
  • MIRN136
• Synonyms
  • hsa-mir-136
• Locus
  14q32.2
• Discovery year
  2004-04-23
• Entrez gene record
  406927
• Pubmed identfication
  • 22967897
• RefSeq identity
  • NR_029699
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:7161
• Gene
  MMP15
• Long gene name
  matrix metallopeptidase 15
• Synonyms gene name
  • matrix metalloproteinase 15 (membrane-inserted)
  • matrix metallopeptidase 15 (membrane-inserted)
• Synonyms
  • MT2-MMP
  • MTMMP2
  • SMCP-2
• GenBank acession
  • Z48482
• Locus
  16q21
• Discovery year
  1996-11-13
• Entrez gene record
  4324
• Pubmed identfication
  • 9070935
  • 9119382
• RefSeq identity
  • NM_002428
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000133466

Gene info

• Identity
  HGNC:14246
• Gene
  MMP25
• Long gene name
  matrix metallopeptidase 25
• Synonyms gene
  • MMPL1
  • MMP20
• Synonyms gene name
  • matrix metalloproteinase 25
  • matrix metallopeptidase-like 1
• Synonyms
  • MT6-MMP
• GenBank acession
  • AF145442
• Locus
  16p13.3
• Discovery year
  2000-12-13
• Entrez gene record
  64386
• Pubmed identfication
  • 10628838
  • 10706098
• RefSeq identity
  • NM_022468
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000177475

MeSH Data

• Name
  Tissue Fixation
• Concept
  Scope note: The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.
• Tree numbers
  • E01.370.225.500.620.760.720
  • E01.370.225.750.600.760.720
  • E05.200.500.620.760.720
  • E05.200.750.600.760.720
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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