TIMP 2 (Native Protein)
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Catalog number30 112 003
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PricePlease ask
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Size200 µg/ 1 ml
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Protein typeNative
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Protein subtypeN/A
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Protein familyNatural inhibitor of the matrix metalloproteinases
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Protein descriptionTIMP-2 complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
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Research area interestsDiseases associated with TIMP2 include Conjunctivochalasis and Inguinal Hernia. Among its related pathways are p70S6K Signaling and CREB Pathway.
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Package formliquid
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Tested applicationsTIMP2 is used to inhibit matrix metalloproteinases. The protein has also been shown to exhibit cell growth-promoting activity
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Other namesTissue Inhibitor Of Metalloproteinase 2, Metalloproteinase Inhibitor 2, Testicular Secretory Protein Li 58
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Peptide sequenceMGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
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Available target modificationYes
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Expression systemhuman fibroblasts
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Product Subtypefull length
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Active formNo
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Taguntagged
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Contents50 mM Tris-HCl, pH 7, 200 mM NaCl, 5 mM CaCl2, 1 μM ZnCl2, 0.05%Brij 35, 0.05% NaN3
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Protein purity>90%
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Molecular weight21 kDa
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UniProt numberP16035
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Gene number7077
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AbbreviationTIMP2
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Full nameTIMP metallopeptidase inhibitor 2
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Other desciptionThe human tissue inhibitor of matrix metalloproteinases TIMP-2 is expressed in Sf9 cells.
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PurificationMentioned in the data sheet
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PubMed citationsSee the data sheet
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WarningsFor Research Use only.
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Shipping conditionsdry ice
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Storage conditionStore at -70°C
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Technical datasheetContact us to receive the datasheet
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Gene target
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Gene symbolTIMP1
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Short nameTIMP 2 (Native Protein)
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SpeciesHomo sapiens
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Alternative nameTIMP 2 (Native Protein)
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Gene info
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Identity
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Gene
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Long gene nameTIMP metallopeptidase inhibitor 1
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Synonyms gene
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Synonyms gene name
- tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
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Synonyms
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Locus
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Discovery year1986-01-01
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Entrez gene record
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RefSeq identity
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Classification
- Tissue inhibitor of metallopeptidases
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VEGA ID
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Locus Specific Databases