TIMP 2 (Native Protein)

  • Catalog number
    30 112 003
  • Price
    Please ask
  • Size
    200 µg/ 1 ml
  • Protein type
    Native
  • Protein subtype
    N/A
  • Protein family
    Natural inhibitor of the matrix metalloproteinases
  • Protein description
    TIMP-2 complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
  • Research area interests
    Diseases associated with TIMP2 include Conjunctivochalasis and Inguinal Hernia. Among its related pathways are p70S6K Signaling and CREB Pathway.
  • Package form
    liquid
  • Tested applications
    TIMP2 is used to inhibit matrix metalloproteinases. The protein has also been shown to exhibit cell growth-promoting activity
  • Other names
    Tissue Inhibitor Of Metalloproteinase 2, Metalloproteinase Inhibitor 2, Testicular Secretory Protein Li 58
  • Peptide sequence
    MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
  • Available target modification
    Yes
  • Expression system
    human fibroblasts
  • Product Subtype
    full length
  • Active form
    No
  • Tag
    untagged
  • Contents
    50 mM Tris-HCl, pH 7, 200 mM NaCl, 5 mM CaCl2, 1 μM ZnCl2, 0.05%Brij 35, 0.05% NaN3
  • Protein purity
    >90%
  • Molecular weight
    21 kDa
  • UniProt number
    P16035
  • Gene number
    7077
  • Abbreviation
    TIMP2
  • Full name
    TIMP metallopeptidase inhibitor 2
  • Other desciption
    The human tissue inhibitor of matrix metalloproteinases TIMP-2 is expressed in Sf9 cells.
  • Purification
    Mentioned in the data sheet
  • PubMed citations
    See the data sheet
  • Warnings
    For Research Use only.
  • Shipping conditions
    dry ice
  • Storage condition
    Store at -70°C
  • Technical datasheet
    Contact us to receive the datasheet
  • Gene target
    TIMP   Native   Protein  
  • Gene symbol
    TIMP1
  • Short name
    TIMP 2 (Native Protein)
  • Species
    Homo sapiens
  • Alternative name
    TIMP 2 (Native Protein)
Gene info
  • Identity
  • Gene
  • Long gene name
    TIMP metallopeptidase inhibitor 1
  • Synonyms gene
  • Synonyms gene name
    • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
  • Synonyms
  • Locus
  • Discovery year
    1986-01-01
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Tissue inhibitor of metallopeptidases
  • VEGA ID
  • Locus Specific Databases
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