Mucin 4 Antibody

• Catalog number
  bs-1994R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Mucin 4 Primary Polyclonal Antibody
• Also known as
  Mucin 4 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Mucin 4
• Specificity
  This is a highly specific antibody against Mucin 4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  1580-1630/2169
• Subcellular location
  Secreted, Cell membrane
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Muc4
• Gene ID number
  4585
• Swiss Prot
  Q99102
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  ASGP; MUC-4; HSA276359; Mucin-4; Ascites sialoglycoprotein; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; MUC4
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Mucin  
• Gene symbol
  MUC4, TIMD4, ADGRE4P
• Short name
  Anti-Mucin 4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Mucin 4 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7514
• Gene
  MUC4
• Long gene name
  mucin 4, cell surface associated
• Synonyms gene name
  • mucin 4, tracheobronchial
• GenBank acession
  • AJ276359
• Locus
  3q29
• Discovery year
  1991-05-22
• Entrez gene record
  4585
• Pubmed identfication
  • 1673336
• RefSeq identity
  • NM_018406
• Classification
  • Mucins
• VEGA ID
  OTTHUMG00000151827

Gene info

• Identity
  HGNC:25132
• Gene
  TIMD4
• Long gene name
  T cell immunoglobulin and mucin domain containing 4
• Synonyms gene name
  • T-cell immunoglobulin and mucin domain containing 4
• Synonyms
  • TIM4
• GenBank acession
  • BC008988
• Locus
  5q33.3
• Discovery year
  2004-07-22
• Entrez gene record
  91937
• Pubmed identfication
  • 18082433
• RefSeq identity
  • NM_138379
• Classification
  • V-set domain containing
• VEGA ID
  OTTHUMG00000130244

Gene info

• Identity
  HGNC:19240
• Gene
  ADGRE4P
• Long gene name
  adhesion G protein-coupled receptor E4, pseudogene
• Synonyms gene
  • GPR127
  • EMR4
  • EMR4P
• Synonyms gene name
  • G protein-coupled receptor 127
  • egf-like module containing, mucin-like, hormone receptor-like 4
  • egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene
• Synonyms
  • PGR16
• GenBank acession
  • AY181245
• Locus
  19p13.2
• Discovery year
  2003-02-25
• Entrez gene record
  326342
• Pubmed identfication
  • 12565841
  • 25713288
• RefSeq identity
  • NR_024075
• Classification
  • Adhesion G protein-coupled receptors, subfamily E
• VEGA ID
  OTTHUMG00000177251

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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