THZ1 (Free base)
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Catalog number9664-25
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PricePlease ask
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Size25 mg
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Alternative_name(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
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DescriptionTHZ1 is a potent, cell-permeable, and selective covalent CDK7 inhibitor (IC₅₀ = 3.2 nM) that preferentially diminishes transcription in cancer cells. It displays unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
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CAS Number1604810-83-4
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₃₁H₂₈ClN₇O₂
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Molecular Weight566.05
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Cell PermeableYes
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Purity≥95% by HPLC
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SolubilitiesDMSO (>30 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent CDK7 inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID73602827
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SMILESCN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
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InChiInChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+
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InChi KeyOBJNFLYHUXWUPF-IZZDOVSWSA-N
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MSDS AvailableYes
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Gene target
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Short nameTHZ1 (Free base)
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Alternative nameTHZ1 (Free base)
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