SMER3, E3 UB ligase inhibitor
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Catalog number
SIH-341-10MG
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Price
Please ask
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Size
10 mg
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Stock availabilitIn Stock
In Stock
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CAS number
67200-34-4
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Description
E3 UB ligase inhibitor
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Molecular weight
224,18 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C11H4N4O2
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in 75 mM DMSO
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Physical appearance
Yellow Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number
568763
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Scientific context
Specific inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin.
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Bibliography
1. Aghajanyy et al. (2010) Nat.Biotechnol. 28: 738.
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Release date
6-Jun-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of SMER3 (SIH-341), a E3 UB ligase inhibitor. CAS #: 67200-34-4. Molecular Formula: C11H4N4O2. Molecular Weight: 224.18 g/mol. Chemical structure of SMER3, a E3 UB ligase inhibitor (SIH-341). CAS # 67200-34-4. Molecular Formula: C11H4N4O2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
SMER3, E3 UB ligase inhibitor
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Alternative name
SMER3, E3 UB ligase suppressor
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MeSH Data
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Name
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Concept
Scope note:
A DNA amplification technique based upon the ligation of OLIGONUCLEOTIDE PROBES. The probes are designed to exactly match two adjacent sequences of a specific target DNA. The chain reaction is repeated in three steps in the presence of excess probe: (1) heat denaturation of double-stranded DNA, (2) annealing of probes to target DNA, and (3) joining of the probes by thermostable DNA ligase. After the reaction is repeated for 20-30 cycles the production of ligated probe is measured.
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Tree numbers
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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