SMER3, E3 UB ligase inhibitor

• Catalog number
  SIH-341-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  67200-34-4
• Description
  E3 UB ligase inhibitor
• Molecular weight
  224,18 g/mol
• Primary research fields
  Cancer, Apoptosis
• Other name
  9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C11H4N4O2
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in 75 mM DMSO
• Physical appearance
  Yellow Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
• PubChem number
  568763
• Scientific context
  Specific inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin.
• Bibliography
  1. Aghajanyy et al. (2010) Nat.Biotechnol. 28: 738.
• Release date
  6-Jun-2012
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of SMER3 (SIH-341), a E3 UB ligase inhibitor. CAS #: 67200-34-4. Molecular Formula: C11H4N4O2. Molecular Weight: 224.18 g/mol. Chemical structure of SMER3, a E3 UB ligase inhibitor (SIH-341). CAS # 67200-34-4. Molecular Formula: C11H4N4O2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  SMER3   ligase   inhibitor  
• Short name
  SMER3, E3 UB ligase inhibitor
• Alternative name
  SMER3, E3 UB ligase suppressor

MeSH Data

• Name
  Ligase Chain Reaction
• Concept
  Scope note: A DNA amplification technique based upon the ligation of OLIGONUCLEOTIDE PROBES. The probes are designed to exactly match two adjacent sequences of a specific target DNA. The chain reaction is repeated in three steps in the presence of excess probe: (1) heat denaturation of double-stranded DNA, (2) annealing of probes to target DNA, and (3) joining of the probes by thermostable DNA ligase. After the reaction is repeated for 20-30 cycles the production of ligated probe is measured.
• Tree numbers
  • E05.393.620.311
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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