TGR5-Receptor-Agonist

  • Catalog number
    B1635-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    TGR5-Receptor-Agonist; TGR5; 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide; MDK00245; MDK-00245; MDK 00245
  • Description
    TGR5 Receptor Agonist, a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
  • CAS Number
    1197300-24-5
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₈H₁₄Cl₂N₂O₂
  • Molecular Weight
    361.22
  • Cell Permeable
    Yes
  • Purity
    >98%
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A potent TGR5 G-protein receptor (GPCR19) agonist
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    NA
  • PubChem CID
    44605616
  • SMILES
    CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)N(C)C3=CC=C(C=C3)Cl
  • InChi
    1S/C18H14Cl2N2O2/c1-11-16(17(21-24-11)14-5-3-4-6-15(14)20)18(23)22(2)13-9-7-12(19)8-10-13/h3-10H,1-2H3
  • InChi Key
    IGRCWJPBLWGNPX-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Additional description
    The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Gene target
  • Gene symbol
    GPBAR1
  • Short name
    TGR5-Receptor-Agonist
  • Alternative name
    TGR5-Receptor-Agonist
Gene info
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