TCR, alpha, beta (T Cell Receptor, T-cell Receptor beta-1 Chain C Region, TRBC1, T-cell Receptor alpha Chain C Region, TRAC, TCRA) (Biotin)
-
Catalog number
GEN632305
-
Price
Please ask
-
Size
100ug
-
-
Also known as
TCR, alpha, beta
-
Other names
TCR, partial; N/A
-
Category
Antibodies
-
Subcategory
Mnoclonal antibodies
-
Gene name
N/A
-
Gene name synonims
N/A
-
Other gene names
N/A
-
Clonality
Monoclonal
-
Immunoglobulin isotype
IgG1
-
Clone
R73
-
Host organism
Mouse (Mus musculus)
-
Source organism
Rat (Rattus norvegicus)
-
Species reactivity
Monkey, Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
-
Specificity and cross reactivity
Detects a T cell specific molecule consisting of two disulphide-linked subunits of 40 and 46kD molecular weight, respectively, on 97% of peripheral rat T cells as defined by the OX-52 marker. 3H2910 is mitogenic for unseparated spleen cells and for purified T cells. In the rat thymus, mature medullary cells express the 3H2910 determinant at the same level as peripheral T cells, whereas 94% of CD4- CD8- thymocytes are 3H2910 negative. It is most likely directed at a constant determinant of the rat alpha/beta heterodimeric T cell antigen receptor. Species Crossreactivity: Clone is reported to crossreact with Cynomolgus monkey (4).; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
-
Purification method
Highly Purified by Ion Exchange chromatography.
-
Form Appearance
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
-
Concentration
N/A
-
Storage and shipping
Store the antibody at -20 degrees Celsius.
-
Tested applications
Flow Cytometry (FC/FACS)
-
Description
The TCR, alpha, beta (T Receptor, T- Receptor beta-1 Chain C Region, TRBC1, T- Receptor alpha Chain C Region, TRAC, TCRA) ( ) is a α- or alpha protein sometimes glycoprotein present in blood. For cells, cell lines and tissues in culture till half confluency. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
-
Properties
Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
-
Conjugation
Biotinylated
-
Gene target
-
Gene symbol
TRAC, TRA, TRBC1, NCOR2
-
Short name
TCR, alpha, beta (T Receptor, T- Receptor beta-1 Chain C Region, TRBC1, T- Receptor alpha Chain C Region, TRAC, TCRA) ( )
-
Label
Biotin
-
Alternative name
Anti-TCR, alpha, beta (T Cell Receptor, T-cell Receptor beta-1 Chain C Region, TRBC1, T-cell Receptor alpha Chain C Region, TRAC, TCRA) (Biotin)
-
Tissue
cell, region
-
Gene info
Gene info
Gene info
Gene info
Similar products
