TARDBP Polyclonal Antibody

• Catalog number
  CAC08048
• Price
  Please ask
• Size
  100 μg

• Other name
  TAR DNA-binding protein 43,TDP-43,TARDBP,TDP43
• Immunogen
  Recombinant Human TAR DNA-binding protein 43 protein (1-396AA)
• Verified reactivity
  Human
• Verified applications
  ELISA,WB,IHC,IF. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200,IF:1:50-1:200
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  Q13148
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Protein G purified, >95%
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  TARDBP  
• Gene symbol
  TARDBP
• Short name
  TARDBP Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  TARDBP polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:11571
• Gene
  TARDBP
• Long gene name
  TAR DNA binding protein
• Synonyms
  • TDP-43
  • ALS10
• GenBank acession
  • U23731
• Locus
  1p36.22
• Discovery year
  2000-01-28
• Entrez gene record
  23435
• Pubmed identfication
  • 7745706
  • 31039256
• RefSeq identity
  • NM_007375
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000002120
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_659

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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