Amiodarone Hydrochloride, Autophagy inducer

• Catalog number
  SIH-393-1G
• Price
  Please ask
• Size
  1 g

• Stock availabilitIn Stock
  In Stock
• CAS number
  19774-82-4
• Description
  Autophagy inducer
• Molecular weight
  681,77 g/mol
• Primary research fields
  Cancer, Autophagy
• Other name
  2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
• Product category
  Small Molecules
• Product type
  Inducer
• Chemical formula
  C25H29I2NO3•HCl
• Origin
  Synthetic
• Purity pourcentage
  >99 %
• Soluble in
  Soluble to 50 mM in DMSO
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by inhalation. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H303- May be harmful if swallowed. H312 + H332- Harmful in contact with skin or if inhaled Precautionary statements: P280- Wear protective gloves/ protective clothing.
• PubChem number
  441325
• Scientific context
  Amiodarone is a non-selective ion channel blocker. It has been found, when used in Saccharomyces cerevisiae, to induce an influx of Ca2+ followed by mitochondrial fragmentation and subsequent cell death. Amiodarone has also been shown to induce autophagy by inhibiting mTORC1. Lastly, Amiodarone has broad-spectrum fungicidal activity.
• Bibliography
  1. Zhang Y., et al. (2007). J Biol Chem. 282(52): 37844-53. 2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.
• Release date
  31-Mar-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Amiodarone Hydrochloride (SIH-393), a Autophagy inducer. CAS #: 19774-82-4. Molecular Formula: C25H29I2NO3.HCl. Molecular Weight: 681.77 g/mol. Chemical structure of Amiodarone Hydrochloride, a Autophagy inducer (SIH-393). CAS # 19774-82-4. Molecular Formula: C25H29I2NO3.HCl.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  1
• Other related products

• Gene target
  Amiodarone   Hydrochloride   Autophagy   inducer  
• Short name
  Amiodarone Hydrochloride, Autophagy inducer
• Alternative name
  Amiodarone Hydrochloride, Autophagy inducer

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