Survivin, human recombinant

• Catalog number
  4160-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  BIRC5; API4; EPR-1
• Alternative_names
  Survivin, BIRC5; API4; EPR-1, Apoptosis inhibitor 4, Apoptosis inhibitor survivin
• Description
  An inhibitor of caspase activatiopoptosis
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Molecular Weight
  18.6 kDa
• Storage Temp
  -20°C
• Shipping
  Blue ice
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and lyophilized with no additives
• Reconstitution Instructions
  Reconstitute to a concentration of 0.1-1.0 mg/ml in PBS.
• Background Information
  Survivin, a member of the inhibitor of apoptosis (IAP) family, is also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 and in humans is encoded by the BIRC5 gene. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Disruption of survivin induction pathways leads to an increase in apoptosis and decrease in tumour growth. Survivin is highly expressed in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells, making survivin an ideal target for studying cancer therapy.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Survivin  
• Gene symbol
  BIRC5
• Short name
  Survivin, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Survivin, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:593
• Gene
  BIRC5
• Long gene name
  baculoviral IAP repeat containing 5
• Synonyms gene
  • API4
• Synonyms gene name
  • apoptosis inhibitor 4
  • baculoviral IAP repeat-containing 5
• Synonyms
  • EPR-1
  • survivin
• Synonyms name
  • survivin variant 3 alpha
• GenBank acession
  • U75285
• Locus
  17q25.3
• Discovery year
  1998-06-10
• Entrez gene record
  332
• Pubmed identfication
  • 8106347
  • 7947793
• RefSeq identity
  • NM_001168
• Classification
  • Baculoviral IAP repeat containing
  • Chromosomal passenger complex
• VEGA ID
  OTTHUMG00000177505

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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