SOX10 (Melanoma Marker) Mouse Monoclonal Antibody

• Catalog number
  MBS439597
• Price
  Please ask
• Size
  0.02 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [SOX10]
• Products_name_syn
  [DOM; PCWH; SOX10; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Waardenburg syndrome type 2E (WS2E); WS4; Waardenburg syndrome type 4C (WS4C)]
• Other_names
  [transcription factor SOX-10; Transcription factor SOX-10; transcription factor SOX-10; SRY-box 10]
• Products_gene_name
  [SOX10]
• Other_gene_names
  [SOX10; SOX10; DOM; WS4; PCWH; WS2E; WS4C]
• Clonality
  Monoclonal
• Clone
  [SOX10/991]
• Reactivity
  Human
• Specificity
  Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  SOX10   Melanoma   Monoclonal  
• Gene symbol
  SOX10
• Short name
  SOX10 (Melanoma ) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG2b, kappa
• Species
  Mouse, Mouses
• Alternative name
  SOX10 (Melanoma detection labelled) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine

Gene info

• Identity
  HGNC:11190
• Gene
  SOX10
• Long gene name
  SRY-box transcription factor 10
• Synonyms gene name
  • SRY (sex determining region Y)-box 10
  • SRY-box 10
• Synonyms
  • DOM
  • WS4
  • WS2E
  • SOX-10
• Synonyms name
  • dominant megacolon, mouse, human homolog of
• Locus
  22q13.1
• Discovery year
  1998-01-22
• Entrez gene record
  6663
• Pubmed identfication
  • 9462749
  • 10441344
  • 12944398
• RefSeq identity
  • NM_006941
• Classification
  • SRY-box transcription factors
• VEGA ID
  OTTHUMG00000149913
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • Global Variome shared LOVD
  • LRG_271

MeSH Data

• Name
  Mammary Neoplasms, Experimental
• Concept
  Scope note: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
• Tree numbers
  • C04.588.531.500
  • C04.619.590
  • E05.598.500.496.843
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, secondary, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, chemistry, psychology, urine, virology, history, blood supply, classification, economics, embryology, genetics, nursing, radiotherapy, prevention & control, pathology, ultrastructure, metabolism, complications, surgery

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