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About recombinant protein
IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. The IL-6Rα chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6Rα. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6Rα which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6Rα is a 37.6 kDa protein consisting of the extracellular domain of the IL-6Rα chain (338 amino acid residues).
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Other name of the recombinant
IL6Q, gp80, CD126, IL6RA, IL6RQ, IL-6RA, IL-6R-1, Interleukin-6 receptor subunit alpha, IL-6R 1, IL-6 receptor subunit alpha
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Recombinant in
HEK293 cells
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Activity
The ED50 was determined by its ability to intensify the IL - 6 induced growth inhibition of murine M1 cells is ≤ 5.0 ng/mL, in the presence of 20 ng/mL of rhIL - 6.
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Keep at
The lyophilized Soluble IL-6 Receptor alpha recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Soluble IL-6 Receptor alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Soluble IL-6 Receptor alpha recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI
4504673
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Accession nr
NP_000556.1
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Pureity
Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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About
This product is for research use only.
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Protein s origin
Human
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Vial
Lyophilized
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NCBI ID
3570
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Gene name
interleukin 6 receptor
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Source
Homo sapiens
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Uniprot
P08887
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Description
The Soluble IL-6 Receptor alpha Recombinant Protein is a α- or alpha protein sometimes glycoprotein present in blood. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
