MOUSE Anti-HUMAN SOCS-3 Antibody
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Catalog numberGEN212753
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PricePlease ask
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Size100ug
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Also known asSOCS-3
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Other namessuppressor of cytokine signaling 3; Suppressor of cytokine signaling 3; suppressor of cytokine signaling 3; CIS-3; STAT-induced STAT inhibitor 3; cytokine-induced SH2 protein 3; cytokine-inducible SH2 protein 3; suppressor of cytokine signaling 3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3
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CategoryAntibodies
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SubcategoryMnoclonal antibodies
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Gene nameSOCS-3
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Gene name synonimsN/A
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Other gene namesSOCS3; SOCS3; CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3; CIS3; SSI3; SOCS-3; CIS-3; SSI-3
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ClonalityMonoclonal
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Immunoglobulin isotypeIgG2b
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CloneSO1
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Host organismMouse (Mus musculus)
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Species reactivityHuman (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivitySOCS-3 This item recognizes suppressor of cytokine signaling 3 (SOCS-3), a 30kDa member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways. _x000D__x000D_SOCS-3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. _x000D_The expression of SOCS-3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohn's Disease. SOCS-3 expression has also been shown to affect IFN alpha sensitivity in tumour studies. Recent studies in mice, have shown Notch signaling plays a critical role in the determination of M1 versus M2 macrophage polarization, and that RBPJ-mediated Notch signaling, regulates this polarization through SOCS-3.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification methodN/A
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Form AppearancePurified (Purified IgG - liquid)
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ConcentrationIg concentration 1.0 mg/ml
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Storage and shippingStore the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. Shelf Life: 18 months from date of dispatch.
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Tested applicationsWestern Blot (WB), ELISA (EIA)
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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TestMBS Monoclonals supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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French translationanticorps
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Gene target
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Gene symbolSOCS3, SOCS3-DT, CISH, SOCS5, SOCS1, MIR1302-3, MIR509-3, MIR7-3
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Short nameMOUSE Anti- SOCS-3 Antibody
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Techniqueanti-Human, Antibody, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, antibodies for, antibodies against human proteins, mouses
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Hostmouse
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SpeciesHuman, Humans, Mouses
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Alternative nameAnti-MOUSE ANTI HUMAN SOCS-3
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Alternative techniqueantibodies, murine
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Gene info
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Identity
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Gene
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Long gene namesuppressor of cytokine signaling 3
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-11-13
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Entrez gene record
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Pubmed identfication
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Classification
- Suppressors of cytokine signaling
- SH2 domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameSOCS3 divergent transcript
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Locus
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Discovery year2020-10-19
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Entrez gene record
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RefSeq identity
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Classification
- Divergent transcripts
Gene info
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Identity
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Gene
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Long gene namecytokine inducible SH2 containing protein
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Synonyms gene name
- cytokine inducible SH2-containing protein
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-09-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Suppressors of cytokine signaling
- SH2 domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesuppressor of cytokine signaling 5
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-11-13
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Pubmed identfication
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Classification
- Suppressors of cytokine signaling
- SH2 domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesuppressor of cytokine signaling 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-11-13
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Pubmed identfication
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Classification
- Suppressors of cytokine signaling
- SH2 domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1302-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1302 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 509-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 7-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR7 family
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data