SLUG Antibody

• Catalog number
  bs-1382R
• Price
  Please ask
• Size
  0.1ml

• Long name
  SLUG Primary Polyclonal Antibody
• Also known as
  SLUG PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  SLUG
• Specificity
  This is a highly specific antibody against SLUG.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  1-50/268
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Slug
• Gene ID number
  6591
• Swiss Prot
  O43623
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  SLUG; WS2D; SLUGH1; SNAIL2; Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2; SNAI2; SLUGH
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SLUG  
• Gene symbol
  SNAI2
• Short name
  Anti-SLUG
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  SLUG Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11094
• Gene
  SNAI2
• Long gene name
  snail family transcriptional repressor 2
• Synonyms gene
  • SLUG
• Synonyms gene name
  • slug homolog, zinc finger protein (chicken)
  • snail homolog 2 (Drosophila)
  • snail family zinc finger 2
• Synonyms
  • SLUGH1
  • SNAIL2
  • SLUGH
• GenBank acession
  • U97060
• Locus
  8q11.21
• Discovery year
  1998-07-03
• Entrez gene record
  6591
• Pubmed identfication
  • 9337409
  • 9721220
• RefSeq identity
  • NM_003068
• Classification
  • Zinc fingers C2H2-type
  • SNAG transcriptional repressors
• VEGA ID
  OTTHUMG00000149912
• Locus Specific Databases
  • LRG_1359

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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