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Target antigen
SIRT7
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB,IHC-P
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Immunogen
E.coli-derived human SIRT7 recombinant protein (Position: R8-G350). Human SIRT7 shares 96% and 95% amino acid (aa) sequence identity with mouse and rat SIRT7, respectively.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the SIRT7 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The SIRT7 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
SIRT7 is also known as SIR2L7. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
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Related articles
1. Altered sirtuin expression is associated with node-positive breast cancer.Ashraf N, et al. Br J Cancer, 2006 Oct 23. 2. Molecular pathways: emerging roles of mammalian Sirtuin SIRT7 in cancer.Paredes S, et al. Clin Cancer Res, 2014 Apr 1. 3. Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis.Tsai YC, et al. Mol Cell Proteomics, 2014 Jan.
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Gene Name
SIRT7
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Protein Name
NAD-dependent protein deacetylase sirtuin-7
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Gene Full Name
sirtuin 7
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Synonyms
NAD dependent deacetylase sirtuin 7 antibody|NAD dependent protein deacetylase sirtuin 7 antibody|NAD-dependent deacetylase sirtuin-7 antibody|Regulatory protein SIR2 homolog 7 antibody|Silent mating type information regulation 2 homolog antibody|Silent mating type information regulation 2 S.cerevisiae homolog 7 antibody|SIR2 L7 antibody|SIR2 like protein 7 antibody|Sir2 related protein type 7 antibody|SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7 antibody|SIR2-like protein 7 antibody|SIR2L 7 antibody|SIR2L7 antibody|SIRT 7 antibody|SIRT7 antibody|SIRT7_HUMAN antibody|Sirtuin 7 antibody|Sirtuin type 7 antibody|Sirtuin7 antibody
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Uniprot ID
Q9NRC8
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Entrez GeneID
51547
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
