SIRT7 (2-400 aa) (His-tagged), Human recombinant
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Catalog number
7675-50
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Price
Please ask
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Size
50 ug
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Synonyms
SIRT7 (2-400 aa) (His-tagged), Human recombinant
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Alternative_names
NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7
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Description
Intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
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Recombinant
Yes
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Source
E. coli
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Purity by SDS PAGE
≥85%
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Assay
SDS-PAGE
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Molecular Weight
49.3 kDa (2-400 aa, NT His Tag)
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Storage Temp
-80°C
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Shipping
dry ice
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Shelf Life
6 months
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Appearance
Liquid
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Physical form description
50 mM sodium phosphate, pH 7.2, 100 mM sodium chloride, 5 mM DTT, and 20% glycerol.
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Background Information
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Conjugation
histidine
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
SIRT7, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2, KRTAP13-2, SNORD114-2
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Short name
SIRT7 (2-400 aa) (His-tagged), recombinant
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Label
his-tagged
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Species
Human, Humans
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Alternative name
SIRT7 (2-400 aa) (histidine-tagged), H. sapiens Rec.
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Alternative technique
rec
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Gene info
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Identity
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Gene
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Long gene name
sirtuin 7
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Synonyms gene name
- sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7
- sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
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GenBank acession
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Locus
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Discovery year
2001-03-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
microRNA 1289-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 521-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 509-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 512-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 7-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 329-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2005-07-11
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
RNA, U6 small nuclear 2
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Synonyms
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Locus
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Discovery year
2008-06-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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