SIRT6 Antibody

• Catalog number
  F43446-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS pH 7.4 with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  SIRT6
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
• Notes
  Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This SIRT6 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q8N6T7
• Purity
  Antigen affinity
• Description
  NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity).
• Immunogen
  A portion of amino acids 276-305 from the human protein was used as the immunogen for this SIRT6 antibody.
• Storage
  Aliquot the SIRT6 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SIRT6  
• Gene symbol
  SIRT6
• Short name
  Anti-SIRT6
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to SIRT6
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:14934
• Gene
  SIRT6
• Long gene name
  sirtuin 6
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
  • sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
• GenBank acession
  • AF233396
• Locus
  19p13.3
• Discovery year
  2001-03-20
• Entrez gene record
  51548
• Pubmed identfication
  • 10873683
• Classification
  • Sirtuins
• VEGA ID
  OTTHUMG00000181847

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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