SIRT2 Inhibitor, B2

• Catalog number
  2085-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, CPNQ
• Description
  Cell-permeable. A Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 µM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.
• CAS Number
  115687-05-3
• Structure Available
  Yes
• Molecular Formula
  C₂₀H₁₇ClN₄O₃
• Molecular Weight
  396.83
• Cell Permeable
  Yes
• Purity
  ≥95%
• Solubilities
  DMSO (>5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent SIRT2 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD02039810
• PubChem CID
  3953303
• PubChem CID Link
• SMILES
  C1CN(CCN1C2=C3C=CC=NC3=C(C=C2)[N+](=O)[O-])C(=O)C4=CC=C(C=C4)Cl
• InChi
  InChI=1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24) 17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2
• InChi Key
  KLNPVNZJCWIQSK-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  SIRT2   Inhibitor  
• Gene symbol
  SIRT2
• Short name
  SIRT2 Inhibitor, B2
• Alternative name
  SIRT2 suppressor, B2

Gene info

• Identity
  HGNC:10886
• Gene
  SIRT2
• Long gene name
  sirtuin 2
• Synonyms gene
  • SIR2L
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
• GenBank acession
  • AF083107
• Locus
  19q13.2
• Discovery year
  1998-10-14
• Entrez gene record
  22933
• Pubmed identfication
  • 10393250
  • 10381378
• Classification
  • Sirtuins
• VEGA ID
  OTTHUMG00000150480

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