Sheep anti Membrane Associated-Guanalyate Kinase GKWW domain (MAGI)

• Catalog number
  K115P
• Price
  Please ask
• Size
  250 μg

• Category
  Primary Antibodies
• Long description
  Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is then followed by 6 PDZ domains.
• Antibody come from
  Recombinant protein corresponding to the guanylate kinase-WW domain of MAGI-3.
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Sheep anti Membrane Associated-Guanalyate Kinase GKWW domain (MAGI) Antibody
• Antibody is raised in
  Sheep
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot
• Antibody s suited for
  Antibody detects MAGI-3 by Western blot at 1-10 µg/ml. Detects a 130 kDa band in cells transfected with full-length MAGI-3 protein. Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Wu, Y., et al. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. J. Biol. Chem. 2000, 275, 21477-21485
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Associated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae. 

• Gene target
  Membrane   Associated-Guanalyate   Kinase   GKWW   domain   MAGI  
• Gene symbol
  MAGI3, MAGI2, MAGI1
• Short name
  anti Associated-Guanalyate Kinase GKWW domain (MAGI)
• Technique
  anti, antibody to
• Host
  Sheep
• Isotype
  not specified
• Label
  unlabeled
• Species
  Sheep, The sheep (Ovis aries) ELISAs are detecting sheep proteins and antigens. Some epitopes will also recognize goat proteins. Sheep and goats are also used to produce polyclonals. An adult female sheep is referred to as a ewe a male as a ram, a castrated male as a wether, and a younger sheep as a lamb. Sheeps
• Alternative name
  ovine antibody to Membrane Associated-Guanalyate phosphorylation catalyst GKWW domain (MAGI)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:29647
• Gene
  MAGI3
• Long gene name
  membrane associated guanylate kinase, WW and PDZ domain containing 3
• Synonyms
  • MAGI-3
• GenBank acession
  • AF213259
• Locus
  1p13.2
• Discovery year
  2005-05-10
• Entrez gene record
  260425
• Pubmed identfication
  • 10997877
  • 10748157
• RefSeq identity
  • NM_152900
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000011737

Gene info

• Identity
  HGNC:18957
• Gene
  MAGI2
• Long gene name
  membrane associated guanylate kinase, WW and PDZ domain containing 2
• Synonyms
  • AIP1
  • ARIP1
  • KIAA0705
  • ACVRIP1
  • MAGI-2
• Synonyms name
  • activin receptor-interacting protein 1
• GenBank acession
  • AB014605
• Locus
  7q21.11
• Discovery year
  2005-05-10
• Entrez gene record
  9863
• Pubmed identfication
  • 10681527
  • 9734811
• RefSeq identity
  • NM_012301
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000130697

Gene info

• Identity
  HGNC:946
• Gene
  MAGI1
• Long gene name
  membrane associated guanylate kinase, WW and PDZ domain containing 1
• Synonyms gene
  • BAIAP1
• Synonyms gene name
  • BAI1-associated protein 1
• Synonyms
  • BAP1
  • MAGI-1
  • TNRC19
  • AIP3
  • WWP3
• GenBank acession
  • AB010894
• Locus
  3p14.1
• Discovery year
  1998-09-29
• Entrez gene record
  9223
• Pubmed identfication
  • 9647739
  • 9225980
• RefSeq identity
  • NM_004742
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000157554

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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