SHEEP ANTI HUMAN LOX-1 Antibody
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Catalog numberMBS221834
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PricePlease ask
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Size50ug
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Alternative name1Anti-SHEEP ANTI HUMAN LOX-1
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Alternative name2Ovine ANTI HUMAN LOX-1
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Alternative name3Ovinae ANTI Homo sapiens LOX-1
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Alternative name4LOX-1
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Alternative name5N/A
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Other namesoxidized low-density lipoprotein receptor 1 isoform 2; Oxidized low-density lipoprotein receptor 1; oxidized low-density lipoprotein receptor 1; hLOX-1; ox LDL receptor 1; lectin-type oxidized LDL receptor 1; scavenger receptor class E, member 1; C-type lectin domain family 8 member A; oxidized low-density lipoprotein receptor 1, soluble form; oxidized low density lipoprotein (lectin-like) receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1; Lectin-type oxidized LDL receptor 1
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Gene nameLOX-1
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Gene name synonimsN/A
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Other gene namesOLR1; OLR1; LOX1; LOXIN; SLOX1; CLEC8A; SCARE1; CLEC8A; LOX1; Ox-LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1
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CategoryAntibodies
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ClonalityPolyclonal
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Immunoglobulin isotypePolyclonal IgG
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ClonePolyclonal antibody
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Host organismSheep
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Species reactivityHuman
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Specificity and cross reactivityLOX-1 This item recognizes the type II membrane glycoprotein LOX-1 (lectin-like oxidized LDL receptor-1), a 40-50kDa class E scavenger receptor, expressed by endothelial cells, macrophages, activated platelets and smooth muscle cells. LOX-1 binds to a wide range of ligands, including oxidized low-density lipoprotein (oxLDL), hypochlorite modified high-density lipoprotein (HDL), aged/apoptotic cells, activated platelets and bacteria, reflecting its versatile physiological functions. This item will detect LOX-1 on transfected cells and in recombinant protein reconstitution assays. LOX-1 levels are low in normal resting human tissues so may fall below detectable levels. Expression of the LOX-1 gene is upregulated by oxLDL and the binding of LOX-1 to oxLDL results in the activation of NF-kappaB. Furthermore, LOX-1 antibodies have been shown to suppress the oxidized HDL (oxHDL) activation of NF-KappaB in endothelial cells, suggesting that this activation may be due to the binding of oxHDL to LOX-1. Angiotensin II and the inflammatory cytokine Tumour Necrosis Factor alpha (TNFalpha) also invoke an increase in LOX-1 gene expression and studies have focused on its role in endothelial dysfunction and inflammatory diseases such as atherosclerosis and rheumatoid arthritis, as well as its affect on CD40/CD40L signaling in both atherosclerosis and human coronary artery endothelial cells (HCAECs).
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Purification methodN/A
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Form AppearancePurified (Purified IgG - liquid)
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ConcentrationIgG concentration 0.1 miligram per 1 mililiter
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Storage and shippingStore at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
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Tested forWestern Blot (WB), Immunohistology - Frozen (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS)
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Descriptionproductone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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AdvisoryIn order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by MBS Polyclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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French translationanticorps
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Gene target
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Gene symbolLOX, ALOX15, OLR1, ALOX12B, ALOX5, ALOX12, ALOX15B, ALOXE3, IGHVII-1-1, MIR1-1
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Short nameANTI LOX-1 Antibody
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Techniqueanti human, Antibody, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
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HostSheep
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SpeciesHuman, Humans, The sheep (Ovis aries) ELISAs are detecting sheep proteins and antigens. Some epitopes will also recognize goat proteins. Sheep and goats are also used to produce polyclonals. An adult female sheep is referred to as a ewe a male as a ram, a castrated male as a wether, and a younger sheep as a lamb. Sheeps
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Alternative nameovine antibody to H. sapiens LOX-1 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namelysyl oxidase
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Synonyms name
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namearachidonate 15-lipoxygenase
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-11-20
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameoxidized low density lipoprotein receptor 1
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Synonyms gene name
- oxidised low density lipoprotein (lectin-like) receptor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-01-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C-type lectin domain containing
- Scavenger receptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 12-lipoxygenase, 12R type
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-07-22
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namearachidonate 5-lipoxygenase
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-07-10
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 12-lipoxygenase, 12S type
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Synonyms gene name
- arachidonate 12-lipoxygenase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-08-07
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate 15-lipoxygenase type B
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Synonyms gene name
- arachidonate 15-lipoxygenase, second type
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-07-22
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearachidonate lipoxygenase 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-11-29
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Entrez gene record
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Pubmed identfication
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Classification
- Arachidonate lipoxygenases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable (II)-1-1 (pseudogene)
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Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1-1
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1/206 family
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
