-
Alternative name1
Anti-SHEEP ANTI HUMAN ERYTHROPOIETIN RECEPTOR
-
Alternative name2
Ovine ANTI HUMAN ERYTHROPOIETIN RECEPTOR
-
Alternative name3
Ovinae ANTI Homo sapiens ERYTHROPOIETIN RECEPTOR
-
Alternative name4
ERYTHROPOIETIN RECEPTOR
-
Alternative name5
N/A
-
Other names
erythropoietin receptor; Erythropoietin receptor; erythropoietin receptor; erythropoietin receptor; N/A
-
Gene name
N/A
-
Gene name synonims
N/A
-
Other gene names
EPOR; EPOR; EPO-R; EPO-R
-
Category
Antibodies
-
Clonality
Polyclonal
-
Immunoglobulin isotype
Polyclonal IgG
-
Clone
Polyclonal antibody
-
Host organism
Sheep
-
Species reactivity
Human
-
Specificity and cross reactivity
ERYTHROPOIETIN RECEPTOR This item recognises Erythropoietin Receptor (EPOR), a type I transmembrane protein and member of the type I cytokine receptor family, expressed by erythroid cells and erythroid progenitor cells, which acts as a receptor for erythropoietin (EPO) to mediate erythroblast proliferation and differentiation, and maintain progenitor survival. Binding of EPO to EPOR, results in the dimerization of the EPOR and the triggering of the JAK2/STAT5 signaling cascade, and in some cell types activation of STAT1 and STAT3. Several isoforms of EPOR exist: EPOR-F, EPOR-S and EPOR-T, and a functional EPOR is found on endothelial cells and cardiomyocytes within the cardiovascular system, suggesting a role in cardiac function. This item has been shown to block Iodine125 labelled erythropoietin ligand binding using erythroleukemia cell line TF-1 with 3000 EPOR/cell in neutralization studies This item is reported as suitable for use in immunocytochemistry. This item has been reported for use in functional studies. Removal of Sodium Azide is recommended prior to use in functional assays. The recommended concentration for functional assays is 500ug/ml.
-
Purification method
N/A
-
Form Appearance
Purified (Purified IgG - liquid)
-
Concentration
IgG concentration 1.0mg/ml
-
Storage and shipping
Store at +Store productone at +4 degrees Celsius.. DO NOT FREEZE. productone should be stored undiluted. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
-
Tested for
Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
-
Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
-
Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
-
Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
-
Properties
If you buy Antibodies supplied by MBS Polyclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
French translation
anticorps