SHANK2 Antibody, ALEXA FLUOR 647

• Catalog number
  bs-11238R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  SHANK2 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-SHANK2 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  SHANK2
• Specificity
  This is a highly specific antibody against SHANK2.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SHANK2
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  SH3 and multiple ankyrin repeat domains 1-3 (Shank1-3) of the Shank/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). The PSD is an electron-dense structure underneath the postsynaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the presynaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). Shank recruits betaPIX and PAK to spines to regulate postsynaptic structure and interacts with NMDA receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  Cortactin binding protein 1; Cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CortBP1; CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; KIAA1022; Proline rich synapse associated protein 1; Proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains protein 2; SHANK; Shank2; Shank2; SPANK3; SPANK-3; SHAN2_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-SHANK2 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  SHANK2  
• Gene symbol
  SHANK2-AS1, SHANK2-AS2, SHANK2-AS3, SHANK2
• Short name
  Anti-SHANK2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  SHANK2 Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40014
• Gene
  SHANK2-AS1
• Long gene name
  SHANK2 antisense RNA 1
• Synonyms gene name
  • SHANK2 antisense RNA 1 (non-protein coding)
• Locus
  11q13.4
• Discovery year
  2011-04-28
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000154610

Gene info

• Identity
  HGNC:40015
• Gene
  SHANK2-AS2
• Long gene name
  SHANK2 antisense RNA 2
• Synonyms gene name
  • SHANK2 antisense RNA 2 (non-protein coding)
• Locus
  11q13.4
• Discovery year
  2011-04-28
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000152738

Gene info

• Identity
  HGNC:25098
• Gene
  SHANK2-AS3
• Long gene name
  SHANK2 antisense RNA 3
• Synonyms gene
  • C11orf76
• Synonyms gene name
  • chromosome 11 open reading frame 76
  • SHANK2 antisense RNA 3 (non-protein coding)
• GenBank acession
  • BC004224
• Locus
  11q13.4
• Discovery year
  2006-03-17
• Entrez gene record
  220070
• Pubmed identfication
  • 12477932
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000150217

Gene info

• Identity
  HGNC:14295
• Gene
  SHANK2
• Long gene name
  SH3 and multiple ankyrin repeat domains 2
• Synonyms gene
  • CORTBP1
• Synonyms gene name
  • cortactin binding protein 1
• Synonyms
  • CTTNBP1
  • ProSAP1
  • SHANK
  • SPANK-3
• GenBank acession
  • AF141901
• Locus
  11q13.3-q13.4
• Discovery year
  2002-02-22
• Entrez gene record
  22941
• Pubmed identfication
  • 10506216
• RefSeq identity
  • NM_012309
• Classification
  • Ankyrin repeat domain containing
  • MicroRNA protein coding host genes
  • PDZ domain containing
  • Sterile alpha motif domain containing
• VEGA ID
  OTTHUMG00000154615

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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