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Category
Proteins & Peptides
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Long description
Sphingolipids play essential roles in various cellular events, including proliferation, differentiation, senescence, apoptosis, and inflammatory responses. Serine palmitoyltransferase (SPT) is the initial and rate-limiting enzyme in the de novo sphingolipid biosynthesis, and thus regulates the level of sphingolipids in cells. Immunohistochemical study revealed widespread distribution of the enzyme with most strong expression in brain and digestive tract. Two subunits, SPT1 and SPT2 at a stoichiometry of 1:1, are involved in the enzymatic activity of SPT.
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Antibody come from
Synthetic peptide derived from the C-terminal domain of the human GPR21 protein.
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Other description
Phosphate buffered saline containing 0.1% sodium azide.
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Clone
not specified
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Antigen antibody binding interaction
Serine Palmitoyltransferase 1 - Blocking Peptide
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Antibody is raised in
see techfile
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Antibody s reacts with
Human
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Western Blot, Immunohistochemistry
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Antibody s suited for
Antibody can be used for immunohistochemistry (10 µg/ml starting dilution). Optimal concentration should be evaluated by serial dilutions.
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Storage
-20ºC
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Relevant references
1. OÕDowd, B.F., et al, Cloning and chromosomal mapping of four putative novel human G-protein coupled receptor genes, Gene 187:75-81(1997)._x000B__x000B_2. The MGC Project Team; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).;Genome Res. 14:2121-2127(2004)._x000B__x000B_3. Bresnick, J.N., et al. 'Identification of signal transduction pathways used by orphan g protein-coupled receptors.' Assay Drug Dev Technol (2003), 1(2), 239-249.
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Test
You can block the antibody by the specific target amino acid sequence of peptide.
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Properties
blocking peptide
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Description
Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs. Serine protease, D- or L-serine arginine rich enzyme of serine threonine kinase with serine that is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an ɑ-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH+
3 form under biological conditions), a carboxyl group. It is non-essential in humans, meaning the body can synthesize it.
