SC-26196

Alternative_name

2,2-diphenyl-5-[4-(pyridin-3-ylmethylideneamino)piperazin-1-yl]pentanenitrile
Description

SC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro. SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.
CAS Number

218136-59-5
Structure Available

Yes
Molecular Formula

C₂₇H₂₉N₅
Molecular Weight

423.55
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~10 mg/ml)
Handling

Protect from air and light
Tag Line

A selective Δ6 desaturase inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
MDL Number

MFCD11226148
PubChem CID

9845201
PubChem CID Link
SMILES

C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4
InChi

C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)/N=C/C4=CN=CC=C4
InChi Key

QFYKXKMYVYOUNJ-JBASAIQMSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:10783
Gene

SRSF2
Long gene name

serine and arginine rich splicing factor 2
Synonyms gene
- SFRS2
Synonyms gene name
- splicing factor, arginine/serine-rich 2
- serine/arginine-rich splicing factor 2
Synonyms
- SC-35
- SC35
- PR264
- SFRS2A
Synonyms name
- SR splicing factor 2
GenBank acession
- M90104
Locus

17q25.2
Discovery year

1993-09-17
Entrez gene record

6427
Pubmed identfication
- 8530103
- 20516191
RefSeq identity
- NM_003016
Classification
- Serine and arginine rich splicing factors
- RNA binding motif containing
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000177547
Locus Specific Databases
- LRG_640