SAHA (Vorinostat), HDAC inhibitor

• Catalog number
  SIH-359-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  149647-78-9
• Description
  HDAC inhibitor
• Molecular weight
  264,3 g/mol
• Primary research fields
  Cell Signaling, Epigenetics, Cancer
• Other name
  Suberoylanilide-hydroxamic acid; Vorinostat; N-Hydroxy-N'-phenyloctanediamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C14H20N2O3
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC), NMR conforms
• Soluble in
  Soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol
• Physical appearance
  White Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H341-H360 (Suspected of causing genetic defects) Precautionary Statements: P201-P281-P308 + P313
• PubChem number
  5311
• Scientific context
  Potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. Synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable.
• Bibliography
  1. Vrana J.A., et al., (1999) Oncogene. 18: 7016. 2. Butler L.M., et al., (2002) Proc. Natl. Acad. Sci. USA. 99: 11700. 3. Tang Y., et al., (2012) Cancer Biol. Ther. 2012 13(7): 567-574.
• Release date
  1-Aug-2012
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of SAHA (Vorinostat) (SIH-359), a HDAC inhibitor. CAS #: 149647-78-9. Molecular Formula: C14H20N2O3. Molecular Weight: 264.3 g/mol. Chemical structure of SAHA (Vorinostat), a HDAC inhibitor (SIH-359). CAS # 149647-78-9. Molecular Formula: C14H20N2O3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  SAHA   Vorinostat   HDAC   inhibitor  
• Gene symbol
  HDAC4, HDAC9
• Short name
  SAHA (Vorinostat), HDAC inhibitor
• Alternative name
  SAHA (Vorinostat), HDAC suppressor

Gene info

• Identity
  HGNC:14063
• Gene
  HDAC4
• Long gene name
  histone deacetylase 4
• Synonyms gene
  • BDMR
• Synonyms gene name
  • brachydactyly-mental retardation syndrome
• Synonyms
  • KIAA0288
  • HDAC-A
  • HDACA
  • HD4
  • HA6116
  • HDAC-4
• GenBank acession
  • AB006626
• Locus
  2q37.3
• Discovery year
  2000-11-28
• Entrez gene record
  9759
• Pubmed identfication
  • 10206986
  • 10220385
  • 20691407
• RefSeq identity
  • NM_006037
• Classification
  • Histone deacetylases, class IIA
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133344

Gene info

• Identity
  HGNC:14065
• Gene
  HDAC9
• Long gene name
  histone deacetylase 9
• Synonyms
  • KIAA0744
  • HDAC
  • MITR
  • HD7
  • HDAC7B
• GenBank acession
  • AF124924
• Locus
  7p21.1
• Discovery year
  2002-09-06
• Entrez gene record
  9734
• Pubmed identfication
  • 10523670
  • 10487760
• Classification
  • Histone deacetylases, class IIA
• VEGA ID
  OTTHUMG00000152487

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