Ryuvidine

• Catalog number
  B1808-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
• Description
  Ryuvidine is a potent inhibitor of SET domain-containing protein 8 (SETD8) (IC₅₀ = 0.5 µM) that suppresses monomethylation of H4K20 in vitro. It displays weak inhibiton against cyclin-dependent kinase 4 (Cdk4; IC₅₀ = 6 µM for Cdk4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.
• CAS Number
  265312-55-8
• Structure Available
  Yes
• Molecular Formula
  C₁₅H₁₂N₂O₂S
• Molecular Weight
  284.33
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (~5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent inhibitor of SET domain-containing protein 8 (SETD8)
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  481747
• PubChem CID Link
• SMILES
  CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C
• InChi
  InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
• InChi Key
  HFPLHASLIOXVGS-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Ryuvidine  
• Short name
  Ryuvidine
• Alternative name
  Ryuvidine

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