Ryanodine Receptor Antibody

• Catalog number
  bs-6305R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Ryanodine Receptor Primary Polyclonal Antibody
• Also known as
  Ryanodine Receptor PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Ryanodine Receptor
• Specificity
  This is a highly specific antibody against Ryanodine Receptor. This antibody will recognize Ryanodine Receptor 1, Ryanodine Receptor 2, and Ryanodine Receptor 3
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  4700-4750/5038
• Subcellular location
  Cytoplasm
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Ryanodine Receptor
• Gene ID number
  6261, 6262, 6263
• Swiss Prot
  P21817, Q92736, Q15413
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The Ryanodine Receptor (RyR) is the channel responsible for calcium release from muscle cell Sarcoplasmic Reticulum (SR) and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains. The remainder of the protein, termed the "foot" region, is located in the cytoplasm between the transverse tubule and the SR. Mammalian RyR isoforms are the product of three different genes: RyR-1 is expressed predominantly in skeletal muscle and areas of the brain; RyR-2 is expressed predominantly in heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain; and RyR-3 is found in smooth muscle and the brain (striatum, thalamus and hippocampus). In non-mammalian vertebrates, the RyR isoforms are termed alpha, beta and cardiac which correlate loosely to the mammalian RyR-1, RyR-3 and RyR-2 isoforms respectively.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Arrhythmogenic right ventricular dysplasia 2; ARVC 2; ARVC2; ARVD 2; ARVD2; Brain ryanodine receptor calcium release channel; Brain type ryanodine receptor; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor calcium release channel; Cardiac muscle type ryanodine receptor; CCO; Central core disease of muscle; HBRR; hRYR 2; hRYR2; MHS; MHS1; Ryanodine receptor 1 skeletal; Ryanodine receptor 1; Ryanodine receptor 2 cardiac; Ryanodine receptor 2; Ryanodine receptor 3; Ryanodine receptor type1; RYDR; RYR 1; RYR 2; RYR 3; RYR; RYR1; RYR2; RYR3; Sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle type ryanodine receptor; SKRR; Type 1 like ryanodine receptor; VTSIP.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• French translation
  anticorps

• Gene target
  Ryanodine   Receptor  
• Gene symbol
  RYR2, RYR3, RYR1
• Short name
  Anti-Ryanodine Receptor
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Ryanodine Receptor Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10484
• Gene
  RYR2
• Long gene name
  ryanodine receptor 2
• Synonyms gene
  • ARVD2
• Synonyms gene name
  • arrhythmogenic right ventricular dysplasia 2
  • ryanodine receptor 2 (cardiac)
• Synonyms
  • ARVC2
  • VTSIP
• GenBank acession
  • X91869
• Locus
  1q43
• Discovery year
  1989-12-07
• Entrez gene record
  6262
• Pubmed identfication
  • 2380170
  • 8406504
  • 11159936
• RefSeq identity
  • NM_001035
• Classification
  • Ryanodine receptors
  • Armadillo like helical domain containing
  • EF-hand domain containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000039543
• Locus Specific Databases
  • Gene Connection for the Heart - Catecholaminergic Polymorphic Ventricular Tachy cardia database
  • LRG_402

Gene info

• Identity
  HGNC:10485
• Gene
  RYR3
• Long gene name
  ryanodine receptor 3
• Locus
  15q13.3-q14
• Discovery year
  1993-05-12
• Entrez gene record
  6263
• Pubmed identfication
  • 8276408
• Classification
  • Ryanodine receptors
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000172253

Gene info

• Identity
  HGNC:10483
• Gene
  RYR1
• Long gene name
  ryanodine receptor 1
• Synonyms gene
  • MHS
  • MHS1
  • CCO
• Synonyms gene name
  • central core disease of muscle
  • ryanodine receptor 1 (skeletal)
• Synonyms
  • RYR
  • PPP1R137
• Synonyms name
  • protein phosphatase 1, regulatory subunit 137
• GenBank acession
  • J05200
• Locus
  19q13.2
• Discovery year
  1989-12-01
• Entrez gene record
  6261
• Pubmed identfication
  • 1862346
  • 16621918
• Classification
  • Ryanodine receptors
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000182403
• Locus Specific Databases
  • Leiden Muscular Dystrophy pages
  • LRG_766

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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