RUNX3 Antibody
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Catalog numberPB9432
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PricePlease ask
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Size0,1 mg
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Target antigenRUNX3
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with specieshuman
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AnalysesWB,IHC-P
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ImmunogenE.coli-derived human RUNX3 recombinant protein (Position: M128-Y270). Human RUNX3 shares 93% amino acid (aa) sequence identity with mouse RUNX3.
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the RUNX3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe RUNX3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundRunt-related transcription factor 3, also called AML2 is a protein that in humans is encoded by the RUNX3 gene. The RUNX3 gene encodes a Runt-related transcription factor, which is part of the RUNX gene family. By fluorescence in situ hybridization, RUNX3 was assigned to human chromosome 1p36.11. RUNX3 binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. It may be involved in the control of cellular proliferation and/or differentiation.
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Related articles1. Brenner, O., Levanon, D., Negreanu, V., Golubkov, O., Fainaru, O., Woolf, E., Groner, Y. Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc. Nat. Acad. Sci. 101: 16016-16021, 2004. 2. Fainaru, O., Shseyov, D., Hantisteanu, S., Groner, Y. Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc. Nat. Acad. Sci. 102: 10598-10603, 2005. 3. Ito, K., Liu, Q., Salto-Tellez, M., Yano, T., Tada, K., Ida, H., Huang, C., Shah, N., Inoue, M., Rajnakova, A., Hiong, K. C., Peh, B. K., Han, H. C., Ito, T., Teh, M., Yeoh, K. G., Ito, Y. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res. 65: 7743-7750, 2005. 4. Li, Q.-L., Ito, K., Sakakura, C., Fukamachi, H., Inoue, K., Chi, X.-Z., Lee, K.-Y., Nomura, S., Lee, C.-W., Han, S.-B., Kim, H.-M., Kim, W.-J., and 15 others. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109: 113-124, 2002.
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Gene NameRUNX3
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Protein NameRunt-related transcription factor 3
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Gene Full Namerunt-related transcription factor 3
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SynonymsAcute myeloid leukemia 2 protein antibody|Acute myeloid leukemia gene 2 antibody|AML 2 antibody|AML2 antibody|CBF alpha 3 antibody|CBF-alpha-3 antibody|CBFA 3 antibody|CBFA3 antibody|Core binding factor alpha 3 subunit antibody|core binding factor antibody|Core binding factor runt domain alpha subunit 3 antibody|Core binding factor subunit alpha 3 antibody|core-binding factor antibody|Core-binding factor subunit alpha-3 antibody|FLJ34510 antibody|MGC16070 antibody|Oncogene AML 2 antibody|Oncogene AML-2 antibody|PEA2 alpha C antibody|PEA2-alpha C antibody|PEBP2 alpha C antibody|PEBP2-alpha C antibody|Pebp2a3 antibody|PEBP2aC antibody|Polyomavirus enhancer binding protein 2 alpha C subunit antibody| Polyomavirus enhancer-binding protein 2 alpha C subunit antibody|runt domain alpha subunit 3 antibody|runt related transcription factor 3 antibody|Runt-related transcription factor 3 antibody|RUNX 3 antibody|Runx3 antibody|RUNX3_HUMAN antibody|SL3 3 enhancer factor 1 alpha C subunit antibody|SL3-3 enhancer factor 1 alpha C subunit antibody|SL3/AKV core binding factor alpha C subunit antibody|SL3/AKV core-binding factor alpha C subunit antibody| Transcription factor AML2 antibody
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Uniprot IDQ13761
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Entrez GeneID864
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolRUNX3-AS1, RUNX3
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Short nameRUNX3 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative namerunt-related transcription factor 3 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetrunt-related transcription factor 3, AML2 and CBFA3 and PEBP2aC, RUNX3 and IDBG-94257 and ENSG00000020633 and 864, ATP binding, nuclei, Runx3 and IDBG-196773 and ENSMUSG00000070691 and 12399, RUNX3 and IDBG-645327 and ENSBTAG00000019800 and 617389
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Gene info
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Identity
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Gene
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Long gene nameRUNX3 antisense RNA 1
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Locus
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Discovery year2020-03-19
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Entrez gene record
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene nameRUNX family transcription factor 3
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Synonyms gene
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Synonyms gene name
- runt-related transcription factor 3
- runt related transcription factor 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-11-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Runt-related transcription factors
- MicroRNA protein coding host genes
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
