RUNX1 (Runt-related Transcription Factor 1, Acute Myeloid Leukemia 1 Protein, Core-binding Factor Subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus Enhancer-binding Protein 2 alpha B Subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 Enhancer Factor 1 a

  • Catalog number
    GEN630769
  • Price
    Please ask
  • Size
    50ug
  • Also known as
    RUNX1
  • Other names
    RUNX1 protein; RUNX1 protein; runt-related transcription factor 1; CBF-alpha-2; PEA2-alpha B; PEBP2-alpha B; aml1 oncogene; oncogene AML-1; OTTHUMP00000108696; OTTHUMP00000108697; OTTHUMP00000108699; OTTHUMP00000108700; OTTHUMP00000108702; AML1-EVI-1 fusion protein; acute myeloid leukemia 1 protein; core-binding factor subunit alpha-2; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; core-binding factor, runt domain, alpha subunit 2; polyomavirus enhancer-binding protein 2 alpha B subunit; runt-related transcription factor 1; N/A
  • Category
    Antibodies
  • Subcategory
    Mnoclonal antibodies
  • Gene name
    RUNX1; RUNX1; AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; N/A
  • Gene name synonims
    RUNX1; RUNX1; AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; N/A
  • Other gene names
    RUNX1; RUNX1; AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; N/A
  • Clonality
    Monoclonal
  • Immunoglobulin isotype
    IgG2b,k
  • Clone
    3A8
  • Host organism
    Mouse (Mus musculus)
  • Source organism
    Human (Homo sapiens)
  • Species reactivity
    Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
  • Specificity and cross reactivity
    Recognizes human RUNX1.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
  • Purification method
    Affinity Purified by Protein A affinity chromatography.
  • Form Appearance
    Supplied as a liquid in PBS, pH 7.2.
  • Concentration
    N/A
  • Storage and shipping
    Store the antibody at +4 degrees Celsius for short term storage.. Aliquot to avoid repeated freezing and thawing. For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
  • Tested applications
    ELISA (EL/EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Description
    The RUNX1 (Runt- Transcription Factor 1, Acute Myeloid Leukemia 1 Protein, Core-binding Factor Subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus Enhancer-binding Protein 2 alpha B Subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 Enhancer Factor 1 a is a α- or alpha protein sometimes glycoprotein present in blood. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.
  • Gene target
    RUNX1   Runt-related   Transcription   Factor   Acute   Myeloid   Leukemia   Protein   Core-binding   Factor   Subunit   alpha-2   CBF-alpha-2   Oncogene   AML-1   Polyomavirus   Enhancer-binding   Protein   alpha   Subunit   PEA2-alpha   PEBP2-alpha   SL3-3   Enhancer   Factor  
  • Gene symbol
    NFYC, RUNX1, NFYB, NFYA, RUNX1-IT1, YWHAZ, TRR-ACG1-3, TRF-GAA1-3, TRR-CCG1-3, MIR3130-1
  • Short name
    RUNX1 (Runt- Transcription Factor 1, Acute Myeloid Leukemia 1 Protein, Core-binding Factor Subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus Enhancer-binding Protein 2 alpha B Subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 Enhancer Factor 1 a
  • Alternative name
    Anti-RUNX1 (Runt-related Transcription Factor 1, Acute Myeloid Leukemia 1 Protein, Core-binding Factor Subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus Enhancer-binding Protein 2 alpha B Subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 Enhancer Factor 1 a
  • Alternative to gene target
    runt-related transcription factor 1, AML1 and AML1-EVI-1 and AMLCR1 and CBFA2 and EVI-1 and PEBP2aB, RUNX1 and IDBG-2825 and ENSG00000159216 and 100506403,101928269,861, repressing transcription factor binding, nuclei, Runx1 and IDBG-177713 and ENSMUSG00000022952 and 12394, RUNX1 and IDBG-640443 and ENSBTAG00000004742 and 529631
  • Virus
    leukemia
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
    HGNC:16623
  • Gene
    RUNX1-IT1
  • Long gene name
    RUNX1 intronic transcript 1
  • Synonyms gene
  • Synonyms gene name
    • chromosome 21 open reading frame 96
    • RUNX1 intronic transcript 1 (non-protein coding)
  • Synonyms
  • GenBank acession
  • Locus
    21q22.12
  • Discovery year
    2003-10-01
  • Entrez gene record
    80215
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Intronic transcripts
Gene info
  • Identity
    HGNC:12855
  • Gene
    YWHAZ
  • Long gene name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  • Synonyms gene
  • Synonyms gene name
    • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
    • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
    8q22.3
  • Discovery year
    1993-09-20
  • Entrez gene record
    7534
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • 14-3-3 phospho-serine/phospho-threonine binding proteins
  • VEGA ID
    OTTHUMG00000134291
Gene info
  • Identity
    HGNC:34806
  • Gene
    TRR-ACG1-3
  • Long gene name
    tRNA-Arg (anticodon ACG) 1-3
  • Synonyms gene
  • Synonyms gene name
    • transfer RNA arginine 21 (anticodon ACG)
    • transfer RNA-Arg (ACG) 1-1
    • transfer RNA-Arg (ACG) 1-3
  • Synonyms
  • GenBank acession
  • Locus
    14q11.2
  • Discovery year
    2008-08-29
  • Entrez gene record
    100189243
  • Classification
    • Cytoplasmic transfer RNAs
Gene info
  • Identity
    HGNC:34984
  • Gene
    TRF-GAA1-3
  • Long gene name
    tRNA-Phe (anticodon GAA) 1-3
  • Synonyms gene
  • Synonyms gene name
    • transfer RNA phenylalanine 11 (anticodon GAA)
    • transfer RNA-Phe (GAA) 1-1
    • transfer RNA-Phe (GAA) 1-3
  • Synonyms
  • GenBank acession
  • Locus
    11q12.1
  • Discovery year
    2008-08-29
  • Entrez gene record
    100189415
  • Classification
    • Cytoplasmic transfer RNAs
Gene info
  • Identity
    HGNC:34735
  • Gene
    TRR-CCG1-3
  • Long gene name
    tRNA-Arg (anticodon CCG) 1-3
  • Synonyms gene
  • Synonyms gene name
    • transfer RNA arginine 19 (anticodon CCG)
    • transfer RNA-Arg (CCG) 1-1
    • transfer RNA-Arg (CCG) 1-3
  • Synonyms
  • GenBank acession
  • Locus
    16p13.3
  • Discovery year
    2008-08-29
  • Entrez gene record
    100189173
  • Classification
    • Cytoplasmic transfer RNAs
Gene info
MeSH Data
  • Name
    Leukemia, Experimental
  • Concept
    Scope note: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
  • Tree numbers
    • C04.557.337.372
    • C04.619.531
    • E05.598.500.496.500
  • Qualifiers
    diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, rehabilitation, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, psychology, urine, virology, history, classification, economics, embryology, genetics, nursing, radiotherapy, ethnology, prevention & control, pathology, metabolism, complications, surgery
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RUNX1 Runt Transcription Factor 1 Acute Myeloid Leukemia 1 P
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