Rottlerin, Autophagy inducer

• Catalog number
  SIH-394-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  82-08-6
• Description
  Autophagy inducer
• Molecular weight
  516,55 g/mol
• Primary research fields
  Cancer, Autophagy
• Other name
  3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
• Product category
  Small Molecules
• Product type
  Inducer
• Chemical formula
  C30H28O8
• Origin
  Synthetic
• Purity pourcentage
  ≥98%
• Soluble in
  Soluble to 2 mM in ethanol and to 20 mM in DMSO.
• Physical appearance
  Orange to brown solid.
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification:Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  5281847
• Scientific context
  Rottlerin has been shown to inhibit protein kinase C as well as CAM kinase III. It is also a potent activator of many K+ channels which are Ca2+-activated. Studies have illustrated Rottlerin to act as a mitochondrial uncoupler which depolarizes membrane potential. Lastly, Rottlerin can induce autophagy by inhibition of mTORC1 signalling.
• Bibliography
  1. Gschwendt M. et al. (1994) Biochem Biophys Res Commun. 199(1): 93-8. 2. Wu S., et al. (2007) J Cell Physiol. 210(3): 655-66. 3. Soltoff S. (2001) J Biol Chem. 276(41): 37986-92. 4. Balgi A., et al. (2009) PLoS One. 4(9): e7124.
• Release date
  31-Mar-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Rottlerin (SIH-394), a Autophagy inducer. CAS #: 82-08-6. Molecular Formula: C30H28O8. Molecular Weight: 516.55 g/mol. Chemical structure of Rottlerin, a Autophagy inducer (SIH-394). CAS # 82-08-6. Molecular Formula: C30H28O8.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products

• Gene target
  Rottlerin   Autophagy   inducer  
• Short name
  Rottlerin, Autophagy inducer
• Alternative name
  Rottlerin, Autophagy inducer

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