RIPK1 Antibody

• Catalog number
  F43338-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  RIPK1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
• Notes
  Titration of the RIPK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This RIPK1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q13546
• Purity
  Antigen affinity
• Description
  Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
• Immunogen
  A portion of amino acids 152-180 from the human protein was used as the immunogen for this RIPK1 antibody.
• Storage
  Aliquot the RIPK1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RIPK1  
• Gene symbol
  RIPK1
• Short name
  Anti-RIPK1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to RIPK1
• Alternative technique
  antibodies
• Alternative to gene target
  receptor (TNFRSF)-interacting serine-threonine kinase 1, RIP and RIP1, RIPK1 and IDBG-57326 and ENSG00000137275 and 8737, transferase activity, Plasma membranes, Ripk1 and IDBG-143710 and ENSMUSG00000021408 and 19766, RIPK1 and IDBG-636679 and ENSBTAG00000006378 and 504727

Gene info

• Identity
  HGNC:10019
• Gene
  RIPK1
• Long gene name
  receptor interacting serine/threonine kinase 1
• Synonyms gene name
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
• Synonyms
  • RIP
• Synonyms name
  • receptor-interacting protein kinase 1
• GenBank acession
  • U25994
• Locus
  6p25.2
• Discovery year
  1999-05-07
• Entrez gene record
  8737
• Pubmed identfication
  • 7538908
  • 8612133
• RefSeq identity
  • NM_003804
• Classification
  • Ripoptosome
• VEGA ID
  OTTHUMG00000014134

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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