RGMA Antibody

• Catalog number
  bs-11473R
• Price
  Please ask
• Size
  0.1ml

• Long name
  RGMA Primary Polyclonal Antibody
• Also known as
  RGMA PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  RGMA
• Specificity
  This is a highly specific antibody against RGMA.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  340-390/450
• Subcellular location
  Cell membrane
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule A
• Gene ID number
  56963
• Swiss Prot
  Q96B86
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  RGM; Repulsive guidance molecule A; RGM domain family member A; RGMA
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RGMA  
• Gene symbol
  RGMA
• Short name
  Anti-RGMA
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  RGMA Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:30308
• Gene
  RGMA
• Long gene name
  repulsive guidance molecule BMP co-receptor a
• Synonyms gene name
  • RGM domain family, member A
  • repulsive guidance molecule family member a
• Synonyms
  • RGM
• GenBank acession
  • AL390083
• Locus
  15q26.1
• Discovery year
  2004-02-04
• Entrez gene record
  56963
• Pubmed identfication
  • 15975920
• RefSeq identity
  • NM_020211
• Classification
  • Repulsive guidance molecule family
• VEGA ID
  OTTHUMG00000171781

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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