RAET1E, human recombinant

• Catalog number
  7327-50
• Price
  Please ask
• Size
  50 ug

• Synonyms
  NKG2D ligand 4, bA350J20.7, LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4
• Alternative_names
  NKG2D ligand 4, bA350J20.7, LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4
• Description
  A ligand for NKG2D receptor
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1.0 EU per 1 microgram of protein
• Molecular Weight
  24.9 kDa (219 aa, 31-225 aa + His Tag), confirmed by MALDI-TOF.
• Storage Temp
  -80°C
• Shipping
  Dry Ice
• Shelf Life
  12 months
• Concentration
  1 mg/ml
• Appearance
  Liquid
• Physical form description
  1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 0.4 M Urea.
• Background Information
  RAET1E belongs to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. RAET1E and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human RAET1E protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MGSMHSLCFN FTIKSLSRPG QPWCEAQVFL NKNLFLQYNS DNNMVKPLGL LGKKVYATST WGELTQTLGE VGRDLRMLLC DIKPQIKTSD PSTLQVEMFC QREAERCTGA SWQFATNGEK SLLFDAMNMT WTVINHEASK IKETWKKDRG LEKYFRKLSK GDCDHWLREF LGHWEAMPEP TVSPVNASDI HWSSSSLPD GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR GNIVGWGVTE IQPHGGAQYV S
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  RAET1E  
• Gene symbol
  RAET1E, RAET1E-AS1
• Short name
  RAET1E, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  retinoic acid early transcript 1E, H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  retinoic acid early transcript 1E, RAET1E and IDBG-97825 and ENSG00000164520 and 135250, natural killer cell lectin-like receptor binding, Extracellular

Gene info

• Identity
  HGNC:16793
• Gene
  RAET1E
• Long gene name
  retinoic acid early transcript 1E
• Synonyms
  • LETAL
  • bA350J20.7
  • ULBP4
• GenBank acession
  • AF359243
• Locus
  6q25.1
• Discovery year
  2003-04-28
• Entrez gene record
  135250
• Pubmed identfication
  • 11827464
• RefSeq identity
  • NM_139165
• VEGA ID
  OTTHUMG00000015796

Gene info

• Identity
  HGNC:48994
• Gene
  RAET1E-AS1
• Long gene name
  RAET1E antisense RNA 1
• Synonyms
  • RAET1G-AS1
• Locus
  6q25.1
• Discovery year
  2013-07-25
• Entrez gene record
  100652739
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000015804

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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