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Alternative_name
Ac-His-Pro-Phe-Val-Statine-Leu-Phe-NH₂; Ac-HPFV-(Sta)-LFNH₂ ; WFML peptide
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Description
Rat renin inhibitor peptide is a specific inhibitor for rat renin (IC₅₀ = 30 nM).
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Structure Available
Y
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Peptide sequence
Ac-His-Pro-Phe-Val-Statine-Leu-Phe-NH₂
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Salt Form
TFA salt
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Molecular Formula
C₅₀H₇₂N₁₀O₉
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Molecular Weight
957.19 (free base)
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Cell Permeable
No
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Purity
≥97% by HPLC
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Solubilities
H₂O (~ 2 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A specific inhibitor of rat renin
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Storage Condition
-20°C
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Shipping Condition
Gel pack
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Shelf Life
24 months
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SMILES
CC(NC(C(N1C(C(NC(C(NC(C(NC(C(CC(NC(C(NC(C(N)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)O)CC(C)C)=O)C(C)C)=)=O)CC3=CC=CC=C3)=O)CCC1)=O)CC4=CNC=N4)=O
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InChi
InChI=1S/C50H72N10O9/c1-29(2)21-36(42(62)26-43(63)55-38(22-30(3)4)46(65)57-37(45(51)64)23-33-15-10-8-11-16-33)56-49(68)44(31(5)6)59-47(66)39(24-34-17-12-9-13-18-34)58-48(67)41-19-14-20-60(41)50(69)40(54-32(7)61)25-35-27-52-28-53-35/h8-13,15-18,27-31,36-42,44,62H,14,19-26H2,1-7H3,(H2,51,64)(H,52,53)(H,54,61)(H,55,63)(H,56,68)(H,57,65)(H,58,67)(H,59,66)
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InChi Key
MMZOSDMFRSWCAY-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin name
Rattus norvegicus
