Recombinant Rat VE-Cadherin / CD144 / CDH5 Protein (Fc tag) 100µg

• Catalog number
  PKSR030270-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  CDH5
• Activity
  NA
• Sequence
  Met1-Gln585
• Fusion tag
  C-Fc
• Accession
  NP_001100877.1
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 75 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  90.7 kDa
• AP Mol Mass
  116 KDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
• Technical Data
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  VE-Cadherin   CD144   CDH5   Protein   tag   100µg  
• Gene symbol
  CDH5, JAM2
• Short name
  Recombinant VE-Cadherin / CD144 / CDH5 Protein (Fc tag) 100µg
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  Fc Tag
• Species
  Rat, Rats
• Alternative name
  Rec. Rat VE-Cadherin / CD144 / cadherin 5, type 2 (vascular endothelium) Protein (fragment c detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  cadherin 5, type 2 (vascular endothelium), 7B4 and CD144, CDH5 and IDBG-34871 and ENSG00000179776 and 1003, ion channel binding, Cell surfaces, Cdh5 and IDBG-185038 and ENSMUSG00000031871 and 12562, BT.64659 and IDBG-633039 and ENSBTAG00000007421 and 414735

Gene info

• Identity
  HGNC:1764
• Gene
  CDH5
• Long gene name
  cadherin 5
• Synonyms gene name
  • cadherin 5, type 2, VE-cadherin (vascular epithelium)
  • cadherin 5, type 2 (vascular endothelium)
• Synonyms
  • 7B4
  • CD144
• Synonyms name
  • VE-cadherin
• GenBank acession
  • X79981
• Locus
  16q21
• Discovery year
  1992-11-20
• Entrez gene record
  1003
• Pubmed identfication
  • 2059658
• RefSeq identity
  • NM_001795
• Classification
  • Type II classical cadherins
  • CD molecules
• VEGA ID
  OTTHUMG00000137495

Gene info

• Identity
  HGNC:14686
• Gene
  JAM2
• Long gene name
  junctional adhesion molecule 2
• Synonyms gene
  • C21orf43
• Synonyms
  • VE-JAM
  • JAM-B
  • JAMB
  • CD322
• GenBank acession
  • AF255910
• Locus
  21q21.3
• Discovery year
  2001-04-25
• Entrez gene record
  58494
• Pubmed identfication
  • 10779521
  • 10945976
• Classification
  • CD molecules
  • Ig-like cell adhesion molecule family
  • I-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000078441

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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