Recombinant Rat ACVR1B / ALK-4 Protein (Fc tag) 100µg

  • Catalog number
    PKSR030351-100µg
  • Price
    Please ask
  • Size
    100µg
  • Synonym
    ACVR1B;Acvrlk4;Alk4
  • Activity
    Measured by its ability to bind with rat TDGF1-His in a functional ELISA.
  • Sequence
    Met1-Glu126
  • Fusion tag
    C-Fc
  • Accession
    NA
  • ExpressedHost
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Endotoxin
    < 1.0 EU per μg of the protein as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    38.4 kDa
  • AP Mol Mass
    42 and 34 KDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Background
    ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
  • About
    Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
  • Latin name
    Rattus norvegicus
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    ACVR1B   ALK-4   Protein   tag   100µg  
  • Gene symbol
    ACVR1B, ALK, ENPP7, MIR1302-4, PIRC18, PIRC16, SNORD114-4, MIR941-4
  • Short name
    Recombinant ACVR1B / ALK-4 Protein (Fc tag) 100µg
  • Technique
    Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Host
    Rat
  • Label
    Fc Tag
  • Species
    Rat, Rats
  • Alternative name
    Rec. Rat activin A receptor, classification IB / anaplastic lymphoma receptor tyrosine kinase-4 Protein (fragment c detection labelled) 100µg
  • Alternative technique
    rec
  • Alternative to gene target
    activin A receptor, type IB, ACTRIB and ACVRLK4 and ALK4 and SKR2, ACVR1B and IDBG-33695 and ENSG00000135503 and 91, activin receptor activity, Cell surfaces, Acvr1b and IDBG-185560 and ENSMUSG00000000532 and 11479, ACVR1B and IDBG-632110 and ENSBTAG00000013555 and 539315
Gene info
Gene info
  • Identity
  • Gene
    ALK
  • Long gene name
    ALK receptor tyrosine kinase
  • Synonyms gene name
    • anaplastic lymphoma kinase (Ki-1)
    • anaplastic lymphoma receptor tyrosine kinase
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1993-08-24
  • Entrez gene record
    238
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Receptor tyrosine kinases
    • CD molecules
  • VEGA ID
  • Locus Specific Databases
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 18
  • Locus
    4
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 16
  • Locus
    4
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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