Recombinant Mouse SFTPD / SP-D / SFTP4 Protein (His tag) 100µg
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Catalog number
PKSM040805-100µg
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Price
Please ask
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Size
100µg
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Activity
NA
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Synonym
AI573415;Sftp4;SP-D
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Sequence
Met 1-Phe 374
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Fusion tag
C-His
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Accession
NP_033186.1
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 97 % as determined by SDS-PAGE
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Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
37.2 kDa
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AP Mol Mass
45 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia and asthma. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.
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Conjugation
histidine
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
SFTPD, SFTPD-AS1, SFTPA1, HOXD13, SNAR-D, REXO5, SPATA1, SPESP1, SFTA2
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Short name
Recombinant Mouse SFTPD / SP-D / SFTP4 Protein (His tag) 100µg
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Technique
Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Host
mouse
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Label
His
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Species
Mouse, Mouses
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Alternative name
Rec. Mouse surfactant protein D / SP-D / SFTP4 Protein (histidine detection labelled) 100µg
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Alternative technique
rec, murine
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Alternative to gene target
surfactant protein D, COLEC7 and PSP-D and SFTP4 and SP-D, SFTPD and IDBG-80187 and ENSG00000133661 and 6441, carbohydrate binding, Extracellular, Sftpd and IDBG-151871 and ENSMUSG00000021795 and 20390, SFTPD and IDBG-631071 and ENSBTAG00000046421 and 282072
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Gene info
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Identity
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Gene
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Long gene name
surfactant protein D
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Synonyms gene
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Synonyms gene name
- surfactant, pulmonary-associated protein D
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Synonyms
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GenBank acession
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Locus
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Discovery year
1992-06-26
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Entrez gene record
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Pubmed identfication
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Classification
- Collectins
- C-type lectin domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
SFTPD antisense RNA 1
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GenBank acession
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Locus
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Discovery year
2015-03-11
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
surfactant protein A1
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Synonyms gene
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Synonyms gene name
- surfactant, pulmonary-associated protein A1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- Collectins
- C-type lectin domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
homeobox D13
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Synonyms gene
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Synonyms gene name
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1991-05-08
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Entrez gene record
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Pubmed identfication
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Classification
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VEGA ID
Gene info
Gene info
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Identity
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Gene
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Long gene name
RNA exonuclease 5
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Synonyms
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GenBank acession
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Locus
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Discovery year
2017-03-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
surfactant associated 2
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Synonyms gene
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Synonyms gene name
- surfactant associated protein G
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Synonyms
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GenBank acession
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Locus
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Discovery year
2002-05-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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