Recombinant Mouse Contactin 1 / CNTN1 Protein (His tag) 200µg

• Catalog number
  PKSM040432-200µg
• Price
  Please ask
• Size
  200µg

• Activity
  NA
• Synonym
  AW495098;CNTN;F3cam;usl
• Sequence
  Met1-Leu1000
• Fusion tag
  C-His
• Accession
  NP_031753.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 90 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  110.5 kDa
• AP Mol Mass
  110-120 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-1 is a cell surface adhesion molecule that is normally expressed by neurons and oligodendrocytes. Particularly high levels of Contactin-1 are present during brain development. Contactin-1 and Contactin-2 are differentially expressed in a number of neuronal tissues during development, and they interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. As a cell adhesion molecule, Contactin-1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that Contactin-1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1. Contactin-1 is also involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that Contactin-1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells. Contactin-1 may also significantly influence the functional expression and distribution of Na+ channels in neurons.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Contactin   CNTN1   Protein   His   tag   200µg  
• Gene symbol
  CNTN1
• Short name
  Recombinant Mouse Contactin 1 / CNTN1 Protein (His tag) 200µg
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse Contactin 1 / contactin 1 Protein (histidine detection labelled) 200µg
• Alternative technique
  rec, murine
• Alternative to gene target
  contactin 1, F3 and GP135 and MYPCN, CNTN1 and IDBG-27462 and ENSG00000018236 and 1272, carbohydrate binding, Plasma membranes, Cntn1 and IDBG-176351 and ENSMUSG00000055022 and 12805, CNTN1 and IDBG-633416 and ENSBTAG00000020679 and 281705

Gene info

• Identity
  HGNC:2171
• Gene
  CNTN1
• Long gene name
  contactin 1
• Synonyms
  • F3
  • GP135
• Synonyms name
  • glycoprotein gP135
• GenBank acession
  • Z21488
• Locus
  12q12
• Discovery year
  1994-02-18
• Entrez gene record
  1272
• Pubmed identfication
  • 7959734
  • 8586965
• RefSeq identity
  • NM_001843
• Classification
  • I-set domain containing
  • Contactins
• VEGA ID
  OTTHUMG00000169362

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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