Recombinant Mouse CNDP1 Protein (His tag)

• Catalog number
  PKSM040417-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  AI746433;Cn1
• Activity
  Measured by its ability to cleave carnosine (ß-Ala-L-His)in a two-step assay.The specific activity is > 250 pmoles/min/μg.
• Sequence
  Met 1-Tyr 492
• Fusion tag
  C-His
• Accession
  Q8BUG2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 93 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  56.5 kDa
• AP Mol Mass
  55 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protection against the adverse effects of high glucose levels on renal cells. In humans, CNDP1 is secreted from the liver into the serum. In other mammals, including rodents, CNDP1 is expressed exclusively within the kidney and lacks a signal peptide. CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine (β-alanyl-L-histidine), and is identified as human carnosinase expressed in the brain. CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans, but not African-Americans. It was identified and confirmed as a risk factor, were cross-sectional and mostly in patients with type 2 diabetes. The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes. In addition, CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CNDP1   Protein   His   tag  
• Gene symbol
  CNDP1
• Short name
  Recombinant Mouse CNDP1 Protein (His tag)
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse CNDP1 Protein (histidine detection labelled)
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:20675
• Gene
  CNDP1
• Long gene name
  carnosine dipeptidase 1
• Synonyms gene name
  • carnosine dipeptidase 1 (metallopeptidase M20 family)
• Synonyms
  • MGC10825
  • CN1
  • CPGL2
  • HsT2308
• Synonyms name
  • carnosinase 1
  • glutamate carboxypeptidase-like protein 2
  • beta-Ala-His dipeptidase
• Locus
  18q22.3
• Discovery year
  2004-04-14
• Entrez gene record
  84735
• Pubmed identfication
  • 12473676
• RefSeq identity
  • NM_032649
• Classification
  • M20 metallopeptidases
• VEGA ID
  OTTHUMG00000132852

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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