Recombinant Human USP7 / HAUSP Protein (aa 208-560)

• Catalog number
  PKSH031028-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  HAUSP;TEF1
• Activity
  NA
• Sequence
  Lys 208-Glu 560
• Fusion tag
  NA
• Accession
  NP_003461.2
• Expressed Host
  Baculovirus-Insect Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞98 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  41 kDa
• AP Mol Mass
  41 kDa
• Formulation
  Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, pH 8.0
• Background
  Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein which belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 stimulates lytic infection and the reactivation of quiescent viral genomes. ICP0 interacts very strongly with USP7. USP7-mediated stabilization of ICP0 is dominant over ICP0-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP0-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP0 are expressed.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  USP7   HAUSP   Protein   208-560  
• Gene symbol
  USP7, USP7-AS1, OR1P1, MIR208A
• Short name
  Recombinant USP7 / HAUSP Protein (aa 208-560)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens USP7 / HAUSP Protein (aa 208-560)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:12630
• Gene
  USP7
• Long gene name
  ubiquitin specific peptidase 7
• Synonyms gene
  • HAUSP
• Synonyms gene name
  • ubiquitin specific peptidase 7 (herpes virus-associated)
• GenBank acession
  • Z72499
• Locus
  16p13.2
• Discovery year
  1998-10-12
• Entrez gene record
  7874
• Pubmed identfication
  • 12838346
  • 9925944
• Classification
  • Ubiquitin specific peptidases
• VEGA ID
  OTTHUMG00000176903

Gene info

• Identity
  HGNC:55379
• Gene
  USP7-AS1
• Long gene name
  USP7 antisense RNA 1
• Locus
  16p13.2
• Discovery year
  2020-11-12
• Entrez gene record
  105371074
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:8222
• Gene
  OR1P1
• Long gene name
  olfactory receptor family 1 subfamily P member 1 (gene/pseudogene)
• Synonyms gene
  • OR1P1P
• Synonyms gene name
  • olfactory receptor, family 1, subfamily P, member 1 pseudogene
  • olfactory receptor, family 1, subfamily P, member 1 (gene/pseudogene)
• Synonyms
  • OR17-208
• GenBank acession
  • AF087927
• Locus
  17p13.3
• Discovery year
  1998-09-14
• Entrez gene record
  8391
• Pubmed identfication
  • 10673334
• RefSeq identity
  • NG_002153
• Classification
  • Olfactory receptors, family 1
• VEGA ID
  OTTHUMG00000177731

Gene info

• Identity
  HGNC:31585
• Gene
  MIR208A
• Long gene name
  microRNA 208a
• Synonyms gene
  • MIRN208
  • MIRN208A
• Synonyms gene name
  • microRNA 208
• Synonyms
  • hsa-mir-208
  • hsa-mir-208a
• Locus
  14q11.2
• Discovery year
  2004-04-23
• Entrez gene record
  406990
• RefSeq identity
  • NR_029595
• Classification
  • MicroRNA MIR208 family

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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