Recombinant Human ROR1 Protein (ECD, His Tag)

• Catalog number
  PKSH030440-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  dJ537F10.1;NTRKR1
• Activity
  NA
• Sequence
  Met1-Glu403
• Fusion tag
  C-His
• Accession
  NP_005003.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  43.4 kDa
• AP Mol Mass
  43.4 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Receptor tyrosine kinase-like orphan receptor 1 (ROR1), also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. At developmental stage, it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ROR1   Protein   ECD   His   Tag  
• Gene symbol
  ROR1, ROR1-AS1, ECD, RORA, SEM1
• Short name
  Recombinant ROR1 Protein (ECD, His Tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens ROR1 Protein (ECD, histidine detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:10256
• Gene
  ROR1
• Long gene name
  receptor tyrosine kinase like orphan receptor 1
• Synonyms gene
  • NTRKR1
• GenBank acession
  • M97675
• Locus
  1p31.3
• Discovery year
  2000-02-29
• Entrez gene record
  4919
• Pubmed identfication
  • 1334494
  • 8875995
• RefSeq identity
  • NM_005012
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000009022

Gene info

• Identity
  HGNC:40508
• Gene
  ROR1-AS1
• Long gene name
  ROR1 antisense RNA 1
• Locus
  1p31.3
• Discovery year
  2014-05-21
• Entrez gene record
  101927034
• Pubmed identfication
  • 31389604
• RefSeq identity
  • NR_110665
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000009024

Gene info

• Identity
  HGNC:17029
• Gene
  ECD
• Long gene name
  ecdysoneless cell cycle regulator
• Synonyms gene name
  • ecdysoneless homolog (Drosophila)
• Synonyms
  • hSGT1
  • GCR2
• GenBank acession
  • BC000721
• Locus
  10q22.2
• Discovery year
  2006-02-06
• Entrez gene record
  11319
• Pubmed identfication
  • 9928932
  • 15128659
• RefSeq identity
  • NM_007265
• VEGA ID
  OTTHUMG00000018451

Gene info

• Identity
  HGNC:10258
• Gene
  RORA
• Long gene name
  RAR related orphan receptor A
• Synonyms gene name
  • RAR-related orphan receptor A
• Synonyms
  • RZRA
  • ROR1
  • ROR2
  • ROR3
  • NR1F1
• GenBank acession
  • U04897
• Locus
  15q22.2
• Discovery year
  1995-04-13
• Entrez gene record
  6095
• Pubmed identfication
  • 7926749
• RefSeq identity
  • NM_134261
• Classification
  • RAR related orphan receptors
• VEGA ID
  OTTHUMG00000132769

Gene info

• Identity
  HGNC:10845
• Gene
  SEM1
• Long gene name
  SEM1 26S proteasome subunit
• Synonyms gene
  • SHFD1
  • SHFM1
  • C7orf76
• Synonyms gene name
  • split hand/foot malformation (ectrodactyly) type 1
  • chromosome 7 open reading frame 76
  • SEM1, 26S proteasome complex subunit
• Synonyms
  • DSS1
  • Shfdg1
  • ECD
  • SHSF1
  • FLJ42280
  • PSMD15
• Synonyms name
  • deleted in split-hand/foot 1
• GenBank acession
  • U41515
• Locus
  7q21.3
• Discovery year
  1991-08-20
• Entrez gene record
  7979
• Pubmed identfication
  • 1895319
  • 8733122
• RefSeq identity
  • NM_006304
• Classification
  • Transcription and export complex 2
  • Proteasome
• VEGA ID
  OTTHUMG00000150680

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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