Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (C-AVI)

• Catalog number
  CA84-500
• Price
  Please ask
• Size
  500 ug

• Description
  Recombinant Human Proprotein Convertase 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln692 is expressed with a AVI tag at the C-terminus.
• Species reactivity
  Human
• Origin
  Human cells
• Peptide sequence
  QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEEAVTAVAICCRSRHLAQASQELQEFGGGLNDIFEAQKIEWHE
• Estimated molecular weight
  71,05 kDa
• Protein purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin level
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Shipping condition
  Dry Ice/ice packs
• Package form
  Supplied as a 0.2 µm filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4.
• Storage conditions
  Store at below -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
• Reconstitution conditions
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 µg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• UniProt number
  Q8NBP7
• Other related products
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Proprotein   Convertase   Subtilisin/Kexin   9/PCSK9   C-AVI  
• Gene symbol
  SMC4, PCSK9, PCK1, MYB, SFTPC, VCX3B, MAF, RFX1, EGR4
• Short name
  Recombinant Proprotein Convertase Subtilisin/Kexin 9/PCSK9 (C-AVI)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. novo advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Human Proprotein Convertase 9/PCSK9(C-AVI)
• Alternative technique
  rec
• Alternative to gene target
  proprotein convertase subtilisin/kexin type 9, PCSK9 and IDBG-99082 and ENSG00000169174 and 255738, very-low-density lipoprotein particle receptor binding, Extracellular, Pcsk9 and IDBG-170186 and ENSMUSG00000044254 and 100102

Gene info

• Identity
  HGNC:14013
• Gene
  SMC4
• Long gene name
  structural maintenance of chromosomes 4
• Synonyms gene
  • SMC4L1
• Synonyms gene name
  • SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
  • SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
• Synonyms
  • hCAP-C
  • CAP-C
• GenBank acession
  • AF092564
• Locus
  3q25.33
• Discovery year
  2001-02-22
• Entrez gene record
  10051
• Pubmed identfication
  • 9789013
  • 10319587
• Classification
  • Structural maintenance of chromosomes proteins
  • Condensin I subunits
  • Condensin II subunits
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000159006

Gene info

• Identity
  HGNC:20001
• Gene
  PCSK9
• Long gene name
  proprotein convertase subtilisin/kexin type 9
• Synonyms gene
  • HCHOLA3
• Synonyms gene name
  • hypercholesterolemia, autosomal dominant 3
• Synonyms
  • NARC-1
  • FH3
• GenBank acession
  • AX207686
• Locus
  1p32.3
• Discovery year
  2003-05-13
• Entrez gene record
  255738
• Pubmed identfication
  • 12552133
  • 12730697
• RefSeq identity
  • NM_174936
• Classification
  • Proprotein convertase subtilisin/kexin family
• VEGA ID
  OTTHUMG00000008136
• Locus Specific Databases
  • British Heart Foundation
  • LRG_275

Gene info

• Identity
  HGNC:8724
• Gene
  PCK1
• Long gene name
  phosphoenolpyruvate carboxykinase 1
• Synonyms gene name
  • phosphoenolpyruvate carboxykinase 1 (soluble)
• Synonyms
  • PEPCK-C
• Locus
  20q13.31
• Discovery year
  1990-09-10
• Entrez gene record
  5105
• Pubmed identfication
  • 1492743
• VEGA ID
  OTTHUMG00000032825

Gene info

• Identity
  HGNC:7545
• Gene
  MYB
• Long gene name
  MYB proto-oncogene, transcription factor
• Synonyms gene name
  • v-myb avian myeloblastosis viral oncogene homolog
• Synonyms
  • c-myb
• Locus
  6q23.3
• Discovery year
  2001-06-22
• Entrez gene record
  4602
• Pubmed identfication
  • 17599807
• Classification
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000015629
• Locus Specific Databases
  • The Globin Gene Server

Gene info

• Identity
  HGNC:10802
• Gene
  SFTPC
• Long gene name
  surfactant protein C
• Synonyms gene
  • SFTP2
• Synonyms gene name
  • surfactant, pulmonary-associated protein C
• Synonyms
  • SP-C
  • PSP-C
  • SMDP2
  • BRICD6
• Synonyms name
  • BRICHOS domain containing 6
• Locus
  8p21.3
• Discovery year
  1988-05-11
• Entrez gene record
  6440
• Pubmed identfication
  • 1859376
  • 16709565
• RefSeq identity
  • NM_003018
• Classification
  • BRICHOS domain containing
• VEGA ID
  OTTHUMG00000163775

Gene info

• Identity
  HGNC:31838
• Gene
  VCX3B
• Long gene name
  variable charge X-linked 3B
• Synonyms
  • VCX-C
• Locus
  Xp22.31
• Discovery year
  2005-01-11
• Classification
  • Variable charge X/Y family
• VEGA ID
  OTTHUMG00000021106

Gene info

• Identity
  HGNC:6776
• Gene
  MAF
• Long gene name
  MAF bZIP transcription factor
• Synonyms gene name
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
• Synonyms
  • c-MAF
• Locus
  16q23.2
• Discovery year
  1991-08-01
• Entrez gene record
  4094
• Pubmed identfication
  • 14998484
• Classification
  • Basic leucine zipper proteins
• VEGA ID
  OTTHUMG00000137621

Gene info

• Identity
  HGNC:9982
• Gene
  RFX1
• Long gene name
  regulatory factor X1
• Synonyms gene name
  • regulatory factor X, 1 (influences HLA class II expression)
• Synonyms
  • EF-C
• Synonyms name
  • trans-acting regulatory factor 1
  • enhancer factor C
  • MHC class II regulatory factor RFX
• Locus
  19p13.12
• Discovery year
  1991-11-06
• Entrez gene record
  5989
• Pubmed identfication
  • 1505960
  • 8289803
• RefSeq identity
  • NM_002918
• Classification
  • Regulatory factor X family
• VEGA ID
  OTTHUMG00000181979

Gene info

• Identity
  HGNC:3241
• Gene
  EGR4
• Long gene name
  early growth response 4
• Synonyms
  • NGFI-C
  • PAT133
• Locus
  2p13.2
• Discovery year
  1992-07-27
• Entrez gene record
  1961
• Pubmed identfication
  • 1584812
• RefSeq identity
  • NM_001965
• Classification
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000129774

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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